Phenotypes associated with this allele

• Allele Symbol: Fbxl12^tm1Kei
• Allele Name: targeted mutation 1, Keiichi I Nakayama
• Allele ID: MGI:5788017
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fbxl12^tm1Kei/Fbxl12^tm1Kei	B6.Cg-Fbxl12^tm1Kei	MGI:5788093

Genotype
MGI:5788093

hm1

• Allelic Composition: Fbxl12^tm1Kei/Fbxl12^tm1Kei
• Genetic Background: B6.Cg-Fbxl12^tm1Kei

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:228662 )

• fewer than expected mice are present at P28

• however, adult mice do not die prematurely

postnatal lethality, incomplete penetrance ( J:228662 )

• despite being born alive, some mice die within the first 48 hours after birth

embryo

abnormal placental labyrinth vasculature morphology ( J:228662 )

• reduced complexity and irregular dilation

embryonic growth retardation ( J:228662 )

• as early as E13.5, more obvious later

abnormal placenta junctional zone morphology ( J:228662 )

• impaired development of the junctional zone regardless of the maternal genotype

small placenta ( J:228662 )

• as early as E13.5, more obvious later

growth/size/body

embryonic growth retardation ( J:228662 )

• as early as E13.5, more obvious later

decreased birth body size ( J:228662 )

postnatal growth retardation ( J:228662 )

• apparent throughout postnatal life

fetal growth retardation ( J:228662 )

behavior/neurological

absent gastric milk in neonates ( J:228662 )

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:228662 )

• reduced complexity and irregular dilation