Analysis Tools
behavior/neurological
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• in response to pentylenetetrazol (PTZ), spike counts increase faster and reach higher levels in mutants than in controls, indicating a lowered threshold for chemically induced seizures
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growth/size/body
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• adults weigh slightly less than controls
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nervous system
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• in response to pentylenetetrazol (PTZ), spike counts increase faster and reach higher levels in mutants than in controls, indicating a lowered threshold for chemically induced seizures
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• accumulation of misfolded, nonfilamentous soluble tau in neurons
• however, mice do not exhibit neuronal loss at 20-23 months of age
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• EEGs in 4-9 month old mice indicated that at baseline, epileptiform spikes are less abundant than in controls
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• mossy fiber synapse between dentate granule cells and CA3 pyramidal neurons exhibits a steeper slope of the input/output curve when fEPSPs are induced, indicating increased synaptic transmission strength at 4-8 months of age, with further increase in strength at 20 months
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• paired-pulse ratio is lower at 20 months, but not a 4-8 months, of age
• however, mossy fiber long-term potentiation is unchanged at old age
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mortality/aging
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• mice survive into old age
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