About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppp3cctm1.1Osb
targeted mutation 1.1, Research Institute for Microbial Diseases, Osaka University
MGI:5788175
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ppp3cctm1.1Osb/Ppp3cctm1.1Osb involves: C57BL/6 * DBA/2 MGI:5788185


Genotype
MGI:5788185
hm1
Allelic
Composition		 Ppp3cctm1.1Osb/Ppp3cctm1.1Osb
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3cctm1.1Osb mutation (0 available); any Ppp3cc mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:226539 )
N
• no overt abnormalities in spermatogenesis, epididymal sperm morphology or sperm counts
• the principal piece of the spermatozoa is normal
abnormal sperm midpiece morphology ( J:226539 )
• slightly bent in the opposite direction from the acrosome hook and inflexible
male infertility ( J:226539 )
• with fewer spermatozoa reaching the ampulla than in wild-type mice
impaired fertilization ( J:226539 )
• in vitro, spermatozoa fail to fertilize cumulus-intact and cumulus-free zona pellucida intact oocytes
• however, sperm can pass through the cumulus cell layer and bind to the zona pellucida and can fertilize zona pellucida-free oocytes

cellular
abnormal sperm midpiece morphology ( J:226539 )
• slightly bent in the opposite direction from the acrosome hook and inflexible




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory