Analysis Tools
mortality/aging
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• high incidence of lethality shortly after weaning
• growth retardation and lethality are due to malnutrition from tooth fragility
• providing mice with a soft food diet starting at weaning restores normal lifespan
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growth/size/body
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• enlarged dental pulp cavity due to reduced dentin
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• 3 week old mice show fractured incisors
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• dramatically reduced layers of dentin in both incisors and molars
• 6 week old and 3 month old mice fed soft food still exhibit a reduced dentin layer
• in P7 molars, the normally organized predentin-dentin layered structure is diminished
• mice show reduced levels of the major noncollagenous dentin matrix proteins DPP and DSP and reduced mRNA levels of Dspp
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• reduction in layer of mineralized dentin and irregular mineralization front
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• 3 week old mice show fractured incisors
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• shortly after weaning, mice present with severe growth retardation
• growth retardation and lethality are due to malnutrition from tooth fragility
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craniofacial
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• enlarged dental pulp cavity due to reduced dentin
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• 3 week old mice show fractured incisors
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• dramatically reduced layers of dentin in both incisors and molars
• 6 week old and 3 month old mice fed soft food still exhibit a reduced dentin layer
• in P7 molars, the normally organized predentin-dentin layered structure is diminished
• mice show reduced levels of the major noncollagenous dentin matrix proteins DPP and DSP and reduced mRNA levels of Dspp
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• reduction in layer of mineralized dentin and irregular mineralization front
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• 3 week old mice show fractured incisors
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behavior/neurological
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• mice exhibit feeding problems due to tooth fragility, impairing mastication
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skeleton
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• enlarged dental pulp cavity due to reduced dentin
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• 3 week old mice show fractured incisors
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• dramatically reduced layers of dentin in both incisors and molars
• 6 week old and 3 month old mice fed soft food still exhibit a reduced dentin layer
• in P7 molars, the normally organized predentin-dentin layered structure is diminished
• mice show reduced levels of the major noncollagenous dentin matrix proteins DPP and DSP and reduced mRNA levels of Dspp
|
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• reduction in layer of mineralized dentin and irregular mineralization front
|
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• 3 week old mice show fractured incisors
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