Phenotypes associated with this allele

• Allele Symbol: Dusp8^tm1Jmol
• Allele Name: targeted mutation 1, Jeffery Molkentin
• Allele ID: MGI:5788467
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dusp8^tm1Jmol/Dusp8^tm1Jmol	involves: 129/SvJ * C57BL/6	MGI:5788567

Genotype
MGI:5788567

hm1

• Allelic Composition: Dusp8^tm1Jmol/Dusp8^tm1Jmol
• Genetic Background: involves: 129/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial fiber morphology ( J:233947 )

• cardiac myocyte length/width ration is reduced in 6 month old mice, however total cardiac myocyte area is similar to control

• cardiac myocytes are thicker and shorter as compared to controls

thick interventricular septum ( J:233947 )

• increase in septal thickness at 2, 4, and 6 months of age

decreased heart left ventricle size ( J:233947 )

• left ventricular chamber dimension during diastole is smaller than controls

increased cardiac muscle contractility ( J:233947 )

• small increase in cardiac contractility at baseline

abnormal cardiac muscle relaxation ( J:233947 )

• faster relaxation times

decreased response of heart to induced stress ( J:233947 )

• following AngII/PE or TAC surgery, cardiac functional performance is maintained better than controls

• following two weeks of stimulation, myocytes are thicker without a matching increase in length

• following I/R injury, thickness in septal wall and LV free wall is maintained; cardiac ventricular performance is similar to sham surgical controls

homeostasis/metabolism

decreased response of heart to induced stress ( J:233947 )

• following AngII/PE or TAC surgery, cardiac functional performance is maintained better than controls

• following two weeks of stimulation, myocytes are thicker without a matching increase in length

• following I/R injury, thickness in septal wall and LV free wall is maintained; cardiac ventricular performance is similar to sham surgical controls

muscle

abnormal myocardial fiber morphology ( J:233947 )

• cardiac myocyte length/width ration is reduced in 6 month old mice, however total cardiac myocyte area is similar to control

• cardiac myocytes are thicker and shorter as compared to controls

increased cardiac muscle contractility ( J:233947 )

• small increase in cardiac contractility at baseline

abnormal cardiac muscle relaxation ( J:233947 )

• faster relaxation times