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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sgtatm1.1Drmcr
targeted mutation 1.1, Dame Roma Mitchell Cancer Research
MGI:5788683
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sgtatm1.1Drmcr/Sgtatm1.1Drmcr involves: C57BL/6 MGI:5788772
ht2
 		Sgtatm1.1Drmcr/Sgta+ involves: C57BL/6 MGI:5788774


Genotype
MGI:5788772
hm1
Allelic
Composition		 Sgtatm1.1Drmcr/Sgtatm1.1Drmcr
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sgtatm1.1Drmcr mutation (1 available); any Sgta mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system

digestive/alimentary system
abnormal intestine morphology ( J:234007 )
• increased intestine weight

endocrine/exocrine glands
abnormal testis development ( J:234007 )
• increased testis descent (AGD)

growth/size/body
increased heart weight ( J:234007 )
decreased body size ( J:234007 )
• small body size observed in both males and females beginning at P19
• feed intake, adiposity, lean and skeletal mass, when corrected for body weight, are similar to controls
decreased body weight ( J:234007 )
decreased body length ( J:234007 )

homeostasis/metabolism

mortality/aging
lethality, incomplete penetrance ( J:234007 )
• heterozygote x heterozygote matings produced fewer female homozygotes than expected (18.80% versus 25%)
neonatal lethality, incomplete penetrance ( J:234007 )
• high neonatal death rate (30.77%) day 2 to 21

nervous system

renal/urinary system
large penis ( J:234007 )
• increased penis length and weight

reproductive system
abnormal testis development ( J:234007 )
• increased testis descent (AGD)
large penis ( J:234007 )
• increased penis length and weight
decreased litter size ( J:234007 )
• litter size trends smaller for homozygote x homozygote matings




Genotype
MGI:5788774
ht2
Allelic
Composition		 Sgtatm1.1Drmcr/Sgta+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sgtatm1.1Drmcr mutation (1 available); any Sgta mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
small stomach ( J:234007 )
• reduced stomach weight

endocrine/exocrine glands
abnormal male preputial gland morphology ( J:234007 )
• increased preputial gland weight

homeostasis/metabolism
decreased circulating insulin-like growth factor I level ( J:234007 )
• decreased serum IGF-1 levels in females

integument
abnormal male preputial gland morphology ( J:234007 )
• increased preputial gland weight

renal/urinary system
abnormal male preputial gland morphology ( J:234007 )
• increased preputial gland weight
large penis ( J:234007 )
• increased penis weight

reproductive system
abnormal male preputial gland morphology ( J:234007 )
• increased preputial gland weight
large penis ( J:234007 )
• increased penis weight




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory