Phenotypes associated with this allele

• Allele Symbol: Akna^tm1Mak
• Allele Name: targeted mutation 1, Tak Mak
• Allele ID: MGI:5788727
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akna^tm1Mak/Akna^tm1Mak	B6.129P2-Akna^tm1Mak	MGI:5789011

Genotype
MGI:5789011

hm1

• Allelic Composition: Akna^tm1Mak/Akna^tm1Mak
• Genetic Background: B6.129P2-Akna^tm1Mak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:233952 )

• most pups die by postnatal day 10

immune system

increased neutrophil cell number ( J:233952 )

• numbers of neutrophils (Cd11b+ Gr1+) in peripheral blood, bone marrow and lung are 2.5 to 3 fold higher than controls

increased acute inflammation ( J:233952 )

• surviving mice exhibit systemic inflammation, mostly in the lungs

lung inflammation ( J:233952 )

alveolitis ( J:233952 )

• enlargement of alveolar airspace is apparent by P7 (increased chord length)

increased susceptibility to fungal infection ( J:233952 )

• increased susceptibility to infection with C. albicans; mice exhibit substantial neutrophil infiltration and alveolar airspace enlargement followed by death, in contrast wild-type controls are resistant, with no changes in lung architecture

hematopoietic system

increased neutrophil cell number ( J:233952 )

• numbers of neutrophils (Cd11b+ Gr1+) in peripheral blood, bone marrow and lung are 2.5 to 3 fold higher than controls

growth/size/body

decreased body size ( J:233952 )

behavior/neurological

weakness ( J:233952 )

respiratory system

lung inflammation ( J:233952 )

alveolitis ( J:233952 )

• enlargement of alveolar airspace is apparent by P7 (increased chord length)