About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Aknatm2Mak
targeted mutation 2, Tak Mak
MGI:5788924
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Aknatm2Mak/Aknatm2Mak B6.129-Aknatm2Mak MGI:5789013


Genotype
MGI:5789013
hm1
Allelic
Composition		 Aknatm2Mak/Aknatm2Mak
Genetic
Background		 B6.129-Aknatm2Mak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aknatm2Mak mutation (0 available); any Akna mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to fungal infection ( J:233952 )
• increased susceptibility to infection with C. albicans
• mice exhibit substantial neutrophil infiltration, airspace enlargement followed by death

mortality/aging
postnatal lethality, incomplete penetrance ( J:233952 )
• most mice do not survive beyond 10 days of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory