Analysis Tools
behavior/neurological
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• mutant mice have abnormal cognition that impacts impulsivity, attention and/or memory
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• mutant mice jump out when their cages were exchanged
• mutant mice jump out of the Y-maze stage before the test starts, while none of the control mice exhibit such behavior
• mutant mice tend to exhibit extreme behavior when transferred to a new environment
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• mutant mice show a lower level of alternation in the Y-maze test, although the total number of arm entry events is the same, suggesting that they have a poor working memory
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• mutant mice exhibit agitated movement in cages when staff personnel enter the breeding room
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• in the Light/Dark transition test at 8 weeks of age, the latency before entering into the light chamber was significantly decreased and the number of transitions was significantly increased
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• hyperactivity, especially when the light conditions are changed or about to be changed
• higher activity during the dark period of the home-cage activity test and partiularly at the light-dark transition periods
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growth/size/body
| N |
• mutant mice do not exhibit growth retardation in the pre- and postnatal periods
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homeostasis/metabolism
| N |
• no urine chemistry abnormalities are detectable in male mutant mice at 10 weeks of age, such as pH or the amount of glucose, total protein, urobilinogen, ketone body, bilirubin and occult blood
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• at 11-13 weeks of age, neuronal norepinephrine levels after release by potassium stimulation are slow to recover
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mortality/aging
| N |
• mutant mice do not exhibit lethality in the pre- and postnatal periods
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renal/urinary system
| N |
• no urine chemistry abnormalities in mutant mice suggests that kidney function is unaltered in mutant mice
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reproductive system
| N |
• male and female mutant mice are fertile, suggesting no required role in sperm and/or egg production
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