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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ticam1M2Btlr
mutation 2, Bruce Beutler
MGI:5789548
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ticam1M2Btlr/Ticam1M2Btlr C57BL/6J-Ticam1M2Btlr MGI:5789768
ht2
 		Ticam1M2Btlr/Ticam1+ C57BL/6J-Ticam1M2Btlr MGI:5789769


Genotype
MGI:5789768
hm1
Allelic
Composition		 Ticam1M2Btlr/Ticam1M2Btlr
Genetic
Background		 C57BL/6J-Ticam1M2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ticam1M2Btlr mutation (0 available); any Ticam1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:234240 )
• mice showed reduced TNF secretion from macrophages in response to the Toll-like receptor 3 (TLR3) ligand, poly(I:C)
decreased macrophage cytokine production ( J:234240 )
• mice showed reduced TNF secretion from macrophages in response to the Toll-like receptor 3 (TLR3) ligand, poly(I:C)
abnormal cytokine secretion ( J:234240 )
• mice showed reduced TNF secretion from macrophages in response to the Toll-like receptor 3 (TLR3) ligand, poly(I:C)
decreased tumor necrosis factor secretion ( J:234240 )
• mice showed reduced TNF secretion from macrophages in response to the Toll-like receptor 3 (TLR3) ligand, poly(I:C)

hematopoietic system
abnormal macrophage physiology ( J:234240 )
• mice showed reduced TNF secretion from macrophages in response to the Toll-like receptor 3 (TLR3) ligand, poly(I:C)
decreased macrophage cytokine production ( J:234240 )
• mice showed reduced TNF secretion from macrophages in response to the Toll-like receptor 3 (TLR3) ligand, poly(I:C)




Genotype
MGI:5789769
ht2
Allelic
Composition		 Ticam1M2Btlr/Ticam1+
Genetic
Background		 C57BL/6J-Ticam1M2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ticam1M2Btlr mutation (0 available); any Ticam1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:234240 )
• mice showed reduced TNF secretion from macrophages in response to the Toll-like receptor 3 (TLR3) ligand, poly(I:C)
decreased macrophage cytokine production ( J:234240 )
• mice showed reduced TNF secretion from macrophages in response to the Toll-like receptor 3 (TLR3) ligand, poly(I:C)
abnormal cytokine secretion ( J:234240 )
• mice showed reduced TNF secretion from macrophages in response to the Toll-like receptor 3 (TLR3) ligand, poly(I:C)
decreased tumor necrosis factor secretion ( J:234240 )
• mice showed reduced TNF secretion from macrophages in response to the Toll-like receptor 3 (TLR3) ligand, poly(I:C)

hematopoietic system
abnormal macrophage physiology ( J:234240 )
• mice showed reduced TNF secretion from macrophages in response to the Toll-like receptor 3 (TLR3) ligand, poly(I:C)
decreased macrophage cytokine production ( J:234240 )
• mice showed reduced TNF secretion from macrophages in response to the Toll-like receptor 3 (TLR3) ligand, poly(I:C)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory