About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Irf4M2Btlr
mutation 2, Bruce Beutler
MGI:5789556
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Irf4M2Btlr/Irf4M2Btlr C57BL/6J-Irf4M2Btlr MGI:5789623
ht2
 		Irf4M2Btlr/Irf4+ C57BL/6J-Irf4M2Btlr MGI:5789624


Genotype
MGI:5789623
hm1
Allelic
Composition		 Irf4M2Btlr/Irf4M2Btlr
Genetic
Background		 C57BL/6J-Irf4M2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf4M2Btlr mutation (0 available); any Irf4 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell activation ( J:234245 )
• mice showed a diminish in T-dependent antibody response (IgG) to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
• mice showed a diminished T-independent antibody (IgM) response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
decreased IgG level ( J:234245 )
• mice showed a diminish in T-dependent antibody response (IgG) to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
decreased IgM level ( J:234245 )
• mice showed a diminished T-independent antibody (IgM) response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

immune system
abnormal B cell activation ( J:234245 )
• mice showed a diminish in T-dependent antibody response (IgG) to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
• mice showed a diminished T-independent antibody (IgM) response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
decreased IgG level ( J:234245 )
• mice showed a diminish in T-dependent antibody response (IgG) to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
decreased IgM level ( J:234245 )
• mice showed a diminished T-independent antibody (IgM) response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)




Genotype
MGI:5789624
ht2
Allelic
Composition		 Irf4M2Btlr/Irf4+
Genetic
Background		 C57BL/6J-Irf4M2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf4M2Btlr mutation (0 available); any Irf4 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell activation ( J:234245 )
• mice showed a slight diminish in T-dependent antibody response (IgG) to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
• mice showed a diminished T-independent antibody (IgM) response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
decreased IgG level ( J:234245 )
• mice showed a slight diminish in T-dependent antibody response (IgG) to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
decreased IgM level ( J:234245 )
• mice showed a diminished T-independent antibody (IgM) response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

hematopoietic system
abnormal B cell activation ( J:234245 )
• mice showed a slight diminish in T-dependent antibody response (IgG) to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
• mice showed a diminished T-independent antibody (IgM) response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
decreased IgG level ( J:234245 )
• mice showed a slight diminish in T-dependent antibody response (IgG) to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
decreased IgM level ( J:234245 )
• mice showed a diminished T-independent antibody (IgM) response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory