About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Naip5m2Btlr
mutation 2, Bruce Beutler
MGI:5789559
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Naip5m2Btlr/Naip5m2Btlr C57BL/6J-Naip5m2Btlr MGI:5789644
ht2
 		Naip5m2Btlr/Naip5+ C57BL/6J-Naip5m2Btlr MGI:5789645


Genotype
MGI:5789644
hm1
Allelic
Composition		 Naip5m2Btlr/Naip5m2Btlr
Genetic
Background		 C57BL/6J-Naip5m2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Naip5m2Btlr mutation (0 available); any Naip5 mutation (103 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:234248 )
• mice exhibited impaired peritoneal macrophage inflammatory responses (i.e., decreased secretion of the proinflammatory cytokine interleukin (IL)-1) in response to priming with flagellin




Genotype
MGI:5789645
ht2
Allelic
Composition		 Naip5m2Btlr/Naip5+
Genetic
Background		 C57BL/6J-Naip5m2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Naip5m2Btlr mutation (0 available); any Naip5 mutation (103 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:234248 )
• mice exhibited slightly impaired peritoneal macrophage inflammatory responses (i.e., decreased secretion of the proinflammatory cytokine interleukin (IL)-1) in response to priming with flagellin




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory