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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nlrp3M10Btlr
mutation 10, Bruce Beutler
MGI:5789569
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nlrp3M10Btlr/Nlrp3M10Btlr C57BL/6J-Nlrp3M10Btlr MGI:5789649
ht2
 		Nlrp3M10Btlr/Nlrp3+ C57BL/6J-Nlrp3M10Btlr MGI:5789650


Genotype
MGI:5789649
hm1
Allelic
Composition		 Nlrp3M10Btlr/Nlrp3M10Btlr
Genetic
Background		 C57BL/6J-Nlrp3M10Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3M10Btlr mutation (0 available); any Nlrp3 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:234254 )
• mice showed a decrease in secretion of the proinflammatory cytokine interleukin (IL)-1beta in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment




Genotype
MGI:5789650
ht2
Allelic
Composition		 Nlrp3M10Btlr/Nlrp3+
Genetic
Background		 C57BL/6J-Nlrp3M10Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3M10Btlr mutation (0 available); any Nlrp3 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:234254 )
• mice showed some decrease in secretion of the proinflammatory cytokine interleukin (IL)-1beta in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory