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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Del(1Aim2-Ifi205)1Stsn
deletion, Chr 1, Daniel Stetson 1
MGI:5789602
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn B6(129S4)-Del(1Aim2-Ifi205)1Stsn MGI:5789963
hm2
 		Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N MGI:5789970
cx3
 		Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn
Trex1tm1Tld/Trex1tm1Tld 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N MGI:5789969
cx4
 		Del(1Aim2-Ifi205)1Stsn/+
Trex1tm1Tld/Trex1tm1Tld 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N MGI:5790350


Genotype
MGI:5789963
hm1
Allelic
Composition		 Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn
Genetic
Background		 B6(129S4)-Del(1Aim2-Ifi205)1Stsn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(1Aim2-Ifi205)1Stsn mutation (1 available); any Del(1Aim2-Ifi205)1Stsn mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased macrophage apoptosis ( J:234263 )
• bone marrow derived macrophages are protected from pyroptotic cell death in response to calf thymus DNA (CT-DNA) as compared to wild type controls

hematopoietic system
decreased macrophage apoptosis ( J:234263 )
• bone marrow derived macrophages are protected from pyroptotic cell death in response to calf thymus DNA (CT-DNA) as compared to wild type controls

immune system
decreased macrophage apoptosis ( J:234263 )
• bone marrow derived macrophages are protected from pyroptotic cell death in response to calf thymus DNA (CT-DNA) as compared to wild type controls
abnormal interferon secretion ( J:234263 )
• production of type I interferon is enhanced in macrophages following transfection with dsDNA (calf thymus DNA)
decreased interleukin-1 beta secretion ( J:234263 )
• macrophages fail to secrete IL1B in response to calf thymus DNA as compared to wild type controls




Genotype
MGI:5789970
hm2
Allelic
Composition		 Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(1Aim2-Ifi205)1Stsn mutation (1 available); any Del(1Aim2-Ifi205)1Stsn mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
stomach inflammation ( J:234263 )
• glandular stomach inflammation

immune system
stomach inflammation ( J:234263 )
• glandular stomach inflammation




Genotype
MGI:5789969
cx3
Allelic
Composition		 Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn
Trex1tm1Tld/Trex1tm1Tld
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(1Aim2-Ifi205)1Stsn mutation (1 available); any Del(1Aim2-Ifi205)1Stsn mutation (1 available)
Trex1tm1Tld mutation (3 available); any Trex1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
heart inflammation ( J:234263 )
• autoantibodies against heart tissue antigens are detected

digestive/alimentary system
stomach inflammation ( J:234263 )
• glandular stomach inflammation

immune system
increased autoantibody level ( J:234263 )
• autoantibodies against heart tissue antigens are detected
increased inflammatory response ( J:234263 )
• inflammation is observed in multiple tissues including heart, tongue, skeletal muscle, glandular stomach, and kidney
heart inflammation ( J:234263 )
• autoantibodies against heart tissue antigens are detected
stomach inflammation ( J:234263 )
• glandular stomach inflammation

mortality/aging
premature death ( J:234263 )
• mice develop a lethal autoimmune disease; death begins at 5 weeks of age
• all mice die by 30 weeks

muscle

renal/urinary system




Genotype
MGI:5790350
cx4
Allelic
Composition		 Del(1Aim2-Ifi205)1Stsn/+
Trex1tm1Tld/Trex1tm1Tld
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(1Aim2-Ifi205)1Stsn mutation (1 available); any Del(1Aim2-Ifi205)1Stsn mutation (1 available)
Trex1tm1Tld mutation (3 available); any Trex1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system

digestive/alimentary system
stomach inflammation ( J:234263 )
• glandular stomach inflammation

immune system
increased autoantibody level ( J:234263 )
• autoantibodies against heart tissue antigens are detected
stomach inflammation ( J:234263 )
• glandular stomach inflammation
myositis ( J:234263 )
• inflammation is observed in multiple tissues including heart, tongue, skeletal muscle, glandular stomach, and kidney

mortality/aging
premature death ( J:234263 )
• mice develop a lethal autoimmune disease; death begins at 5 weeks of age
• all mice die by 30 weeks

muscle
myositis ( J:234263 )
• inflammation is observed in multiple tissues including heart, tongue, skeletal muscle, glandular stomach, and kidney

renal/urinary system




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory