Phenotypes associated with this allele

• Allele Symbol: Hotair^tm1.1Hyc
• Allele Name: targeted mutation 1.1, Howard Chang
• Allele ID: MGI:5789897
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hotair^tm1.1Hyc/Hotair^tm1.1Hyc	B6.Cg-Hotair^tm1.1Hyc	MGI:5789903

Genotype
MGI:5789903

hm1

• Allelic Composition: Hotair^tm1.1Hyc/Hotair^tm1.1Hyc
• Genetic Background: B6.Cg-Hotair^tm1.1Hyc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal carpal bone morphology ( J:203783 )

• 56% of mice have abnormalities in metacarpal and carpal bones including fusions and missing bony elements

• 78% of mice exhibit one or more of the abnormalities

fused carpal bones ( J:203783 )

• fusion of carpal elements c-3

absent radius ( J:203783 )

abnormal metacarpal bone morphology ( J:203783 )

• 56% of mice have abnormalities in metacarpal and carpal bones including fusions and missing bony elements

• 78% of mice exhibit one or more of the abnormalities

fused metacarpal bones ( J:203783 )

• fusion of carpal/metacarpal elements 1-2-c

caudal vertebral transformation ( J:203783 )

• L6 to S1 lumbar-sacral transition

skeleton

abnormal carpal bone morphology ( J:203783 )

• 56% of mice have abnormalities in metacarpal and carpal bones including fusions and missing bony elements

• 78% of mice exhibit one or more of the abnormalities

fused carpal bones ( J:203783 )

• fusion of carpal elements c-3

absent radius ( J:203783 )

abnormal metacarpal bone morphology ( J:203783 )

• 56% of mice have abnormalities in metacarpal and carpal bones including fusions and missing bony elements

• 78% of mice exhibit one or more of the abnormalities

fused metacarpal bones ( J:203783 )

• fusion of carpal/metacarpal elements 1-2-c

caudal vertebral transformation ( J:203783 )

• L6 to S1 lumbar-sacral transition

decreased lumbar vertebrae number ( J:203783 )

• 58% of mice have 5 rather than 6 lumbar vertebrae

lumbar vertebral transformation ( J:203783 )

• transformation of caudal 4 vertebrae

• L6 to S1 lumbar-sacral transition