Phenotypes associated with this allele

• Allele Symbol: Nars2^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:5790096
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nars2^em1(IMPC)J/Nars2^em1(IMPC)J	C57BL/6NJ-Nars2^em1(IMPC)J/J	MGI:6262967
hm2	Nars2^em1(IMPC)J/Nars2^em1(IMPC)J	C57BL/6N-Nars2^em1(IMPC)J/Mmucd	MGI:7736164
ht3	Nars2^em1(IMPC)J/Nars2^+	C57BL/6NJ-Nars2^em1(IMPC)J/J	MGI:6262966

Genotype
MGI:6262967

hm1

• Allelic Composition: Nars2^em1(IMPC)J/Nars2^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Nars2^em1(IMPC)J/J

Data Sources

IMPC Data for Nars2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:7736164

hm2

• Allelic Composition: Nars2^em1(IMPC)J/Nars2^em1(IMPC)J
• Genetic Background: C57BL/6N-Nars2^em1(IMPC)J/Mmucd

Nars2^em1(IMPC)J/\AlleleSymbol(MGI:5790096|0 mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and form a rudimentary egg cylinder but no primitive streak or hallmarks of gastrulation are seen at E7.5.

mortality/aging

embryonic lethality prior to organogenesis ( J:279207 )

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• homozygous embryos are recovered in expected Mendelian ratios at E7.5 but arrest prior to gastrulation; no homozygous embryos are recovered at E9.5

embryo

failure to gastrulate ( J:290315 , J:279207 )

• no morphological hallmarks typical of gastrulating embryos are observed at E7.5 (J:279207)

embryonic growth arrest ( J:279207 )

• embryos arrest prior to gastrulation

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

• no Brachyury (T)-positive cells are present at E7.5, indicating failure of primitive streak initiation

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

Genotype
MGI:6262966

ht3

• Allelic Composition: Nars2^em1(IMPC)J/Nars2⁺
• Genetic Background: C57BL/6NJ-Nars2^em1(IMPC)J/J

Data Sources

IMPC Data for Nars2

behavior/neurological

decreased exploration in new environment ( J:211773 )

♂

IMPC - JAX

decreased thigmotaxis ( J:211773 )

♂

IMPC - JAX

decreased locomotor activity ( J:211773 )

♂

IMPC - JAX