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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nars2em1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:5790096
Summary 3 genotypes


Genotype
MGI:6262967
hm1
Allelic
Composition		 Nars2em1(IMPC)J/Nars2em1(IMPC)J
Genetic
Background		 C57BL/6NJ-Nars2em1(IMPC)J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nars2em1(IMPC)J mutation (1 available); any Nars2 mutation (15 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7736164
hm2
Allelic
Composition		 Nars2em1(IMPC)J/Nars2em1(IMPC)J
Genetic
Background		 C57BL/6N-Nars2em1(IMPC)J/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nars2em1(IMPC)J mutation (1 available); any Nars2 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Nars2em1(IMPC)J/\AlleleSymbol(MGI:5790096|0 mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and form a rudimentary egg cylinder but no primitive streak or hallmarks of gastrulation are seen at E7.5.

mortality/aging
embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )
• homozygous embryos are recovered in expected Mendelian ratios at E7.5 but arrest prior to gastrulation; no homozygous embryos are recovered at E9.5

embryo
failure to gastrulate ( J:290315 , J:279207 )
• no morphological hallmarks typical of gastrulating embryos are observed at E7.5 (J:279207)
embryonic growth arrest ( J:279207 )
• embryos arrest prior to gastrulation
decreased embryo size ( J:279207 )
• embryos are much smaller than controls at E7.5
absent head fold ( J:279207 )
• no head folds are present at E7.5
absent primitive node ( J:279207 )
• no embryonic node is present at E7.5
failure of primitive streak formation ( J:279207 )
• no morphological evidence of primitive streak formation is observed at E7.5
• no Brachyury (T)-positive cells are present at E7.5, indicating failure of primitive streak initiation

growth/size/body
decreased embryo size ( J:279207 )
• embryos are much smaller than controls at E7.5




Genotype
MGI:6262966
ht3
Allelic
Composition		 Nars2em1(IMPC)J/Nars2+
Genetic
Background		 C57BL/6NJ-Nars2em1(IMPC)J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nars2em1(IMPC)J mutation (1 available); any Nars2 mutation (15 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

integument

pigmentation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory