Analysis Tools
skeleton
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• the number of osteoclasts is increased along the diaphyseal endocortical surface
• however, number of osteoclasts is normal in trabecular bone
• in 8 day growing mice, the number of osteoclasts along the endosteum is increased
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• expanded metaphyses
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• width of bones at the midshaft is increased
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• thin cortical bone in femora and tibiae in 2 week old mice
• thin cortical bone in the calvaria
• treatment with a sclerostin-neutralizing antibody increases cortical bone thickness
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• decrease in cortical bone formation
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• rates of periosteal and endocortical mineral apposition are equally reduced
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• increase in bone-formation rates
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• failure of bone remodeling during growth
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• increase in endocortical bone resorption
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• reduction in mechanical strength measured at the diaphysis
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hematopoietic system
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• the number of osteoclasts is increased along the diaphyseal endocortical surface
• however, number of osteoclasts is normal in trabecular bone
• in 8 day growing mice, the number of osteoclasts along the endosteum is increased
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immune system
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• the number of osteoclasts is increased along the diaphyseal endocortical surface
• however, number of osteoclasts is normal in trabecular bone
• in 8 day growing mice, the number of osteoclasts along the endosteum is increased
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limbs/digits/tail
