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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Clrn2mpc169H
muta-ped-c3pde 169, Harwell
MGI:5792002
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Clrn2mpc169H/Clrn2mpc169H C57BL/6J-Clrn2mpc169H MGI:6458827
hm2
Clrn2mpc169H/Clrn2mpc169H involves: BALB/c * C3H/HeH * C57BL/6J MGI:5792370
ht3
Clrn2em1H/Clrn2mpc169H involves: C57BL/6J MGI:6458828


Genotype
MGI:6458827
hm1
Allelic
Composition
Clrn2mpc169H/Clrn2mpc169H
Genetic
Background
C57BL/6J-Clrn2mpc169H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clrn2mpc169H mutation (0 available); any Clrn2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
N
• mice exhibit normal balance function and proper polarization of the hair bundle
• inner hair cells lack fast-graded voltage responses
• however, outer hair cell function is normal
• impaired mechano-electrical transduction
• at P16 with progressive increase at P21, P28, and P42
• severe at 3 months of age

vision/eye
N
• mice exhibit no overt retinal deficits

nervous system
• inner hair cells lack fast-graded voltage responses
• however, outer hair cell function is normal
• impaired mechano-electrical transduction




Genotype
MGI:5792370
hm2
Allelic
Composition
Clrn2mpc169H/Clrn2mpc169H
Genetic
Background
involves: BALB/c * C3H/HeH * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clrn2mpc169H mutation (0 available); any Clrn2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear




Genotype
MGI:6458828
ht3
Allelic
Composition
Clrn2em1H/Clrn2mpc169H
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clrn2em1H mutation (1 available); any Clrn2 mutation (26 available)
Clrn2mpc169H mutation (0 available); any Clrn2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• very elevated at all frequencies tested





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory