hearing/vestibular/ear
N |
• mice exhibit normal balance function and proper polarization of the hair bundle
|
• inner hair cells lack fast-graded voltage responses
• however, outer hair cell function is normal
|
• impaired mechano-electrical transduction
|
• at P16 with progressive increase at P21, P28, and P42
• severe at 3 months of age
|
• reduced at P28
|
vision/eye
N |
• mice exhibit no overt retinal deficits
|
nervous system
• inner hair cells lack fast-graded voltage responses
• however, outer hair cell function is normal
|
• impaired mechano-electrical transduction
|