Phenotypes associated with this allele

• Allele Symbol: Idh3a^mpc201H
• Allele Name: muta-ped-c3pde 201, Harwell
• Allele ID: MGI:5792025
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Idh3a^mpc201H/Idh3a^mpc201H	involves: BALB/c * C3H/HeH * C57BL/6J	MGI:5792350
hm2	Idh3a^mpc201H/Idh3a^mpc201H	involves: C57BL/6J	MGI:6358220
ht3	Idh3a^mpc201H/Idh3a^em1Jkn	involves: C57BL/6J	MGI:6358221

Genotype
MGI:5792350

hm1

• Allelic Composition: Idh3a^mpc201H/Idh3a^mpc201H
• Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

increased susceptibility to age-related retinal degeneration ( J:234901 )

• progressive retina degeneration

decreased visual acuity ( J:234901 )

• from 12 months

Genotype
MGI:6358220

hm2

• Allelic Composition: Idh3a^mpc201H/Idh3a^mpc201H
• Genetic Background: involves: C57BL/6J

vision/eye

increased susceptibility to age-related retinal degeneration ( J:267900 )

• no loss of cells at age P60

• normal a-wave amplitude and electroretinogram (ERG) trace at age P60

• progressive loss of nuclei in outer nuclear layer (ONL) from age P90

• significantly reduced a-wave amplitude and scotopic ERG response

decreased visual acuity ( J:267900 )

• progressive decline in visual acuity by age 12 months, as determined by optokinetic drum (OKD) score

Genotype
MGI:6358221

ht3

• Allelic Composition: Idh3a^mpc201H/Idh3a^em1Jkn
• Genetic Background: involves: C57BL/6J

vision/eye

increased susceptibility to age-related retinal degeneration ( J:267900 )

• loss of significant portion of nuclei in outer nuclear layer (ONL) at age P60, progressing further by P90

• significantly reduced a-wave response and flatline ERG trace at age P60

• normal retinal function at age P30 as determined by electroretinograms (ERGs)