Analysis Tools
homeostasis/metabolism
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• significantly increased serum ferritin levels at 10 weeks of age
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• significantly elevated transferrin saturation at 10 weeks of age
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• 13.1-fold decrease in hepcidin mRNA expression in liver
• 2.4-fold increase in hepatic BMP6 mRNA levels
• marked up-regulation of ferroportin in the duodenum
• however, duodenal BMP6 mRNA expression is largely normal
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• 2.4-fold reduction of nonheme iron levels in spleen at 10 weeks of age
• splenic macrophages are iron-deficient
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• significantly increased serum iron levels at 10 weeks of age
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• 12.9-fold increase of nonheme iron levels in liver at 10 weeks of age, as determined by ferrozine assay
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• deposits of nonheme iron in parenchymal cells of the liver, pancreas, and heart at 10 weeks of age
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hematopoietic system
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• splenic macrophages are iron-deficient
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• 2.4-fold reduction of nonheme iron levels in spleen at 10 weeks of age
• splenic macrophages are iron-deficient
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liver/biliary system
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• 12.9-fold increase of nonheme iron levels in liver at 10 weeks of age, as determined by ferrozine assay
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immune system
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• splenic macrophages are iron-deficient
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• 2.4-fold reduction of nonheme iron levels in spleen at 10 weeks of age
• splenic macrophages are iron-deficient
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