Phenotypes associated with this allele

• Allele Symbol: Tubgcp4^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:5792574
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tubgcp4^em1(IMPC)J/Tubgcp4^em1(IMPC)J	C57BL/6NJ-Tubgcp4^em1(IMPC)J/J	MGI:6263795
ht2	Tubgcp4^em1(IMPC)J/Tubgcp4^+	C57BL/6NJ-Tubgcp4^em1(IMPC)J/J	MGI:6461781

Genotype
MGI:6263795

hm1

• Allelic Composition: Tubgcp4^em1(IMPC)J/Tubgcp4^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Tubgcp4^em1(IMPC)J/J

Data Sources

IMPC Data for Tubgcp4

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Tubgcp4^em1(IMPC)J/Tubgcp4^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts grown in vitro fail to hatch from the zona pellucida with apparent cell death.

embryo

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• blastocysts fail to hatch from the zona pellucida with apparent cell death after 3 days in culture

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• normal blastocysts are recovered at E3.5 (15% versus expected 25%, n=46); no homozygous embryos are recovered at E7.5

Genotype
MGI:6461781

ht2

• Allelic Composition: Tubgcp4^em1(IMPC)J/Tubgcp4⁺
• Genetic Background: C57BL/6NJ-Tubgcp4^em1(IMPC)J/J

Data Sources

IMPC Data for Tubgcp4

behavior/neurological

hyperactivity ( J:211773 )

♂

IMPC - JAX

integument

abnormal vibrissa morphology ( J:211773 )

♀

IMPC - JAX

absent vibrissae ( J:211773 )

♀

IMPC - JAX