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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Snrktm1Rra
targeted mutation 1, Ramani Ramchandran
MGI:5792702
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Snrktm1Rra/Snrktm1Rra involves: C57BL/6J MGI:5792709


Genotype
MGI:5792709
hm1
Allelic
Composition		 Snrktm1Rra/Snrktm1Rra
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snrktm1Rra mutation (0 available); any Snrk mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:218247 )
• mice do not survive beyond 24 hr after birth

homeostasis/metabolism
abnormal lipid level ( J:218247 )
• neonatal hearts fail to stain positive for neutral lipids using oil red O (ORO)
• however, other tissues stain positive for ORO and mice exhibit normal plasma phospholipid levels
decreased circulating free fatty acids level ( J:218247 )
• non-esterified and esterified fatty acids

cardiovascular system
cardiovascular system phenotype ( J:218247 )
N
• mice exhibit normal right ventricle and cardiac tissue proliferation or apoptosis
enlarged heart ( J:218247 )
• at E17.5 and P0

growth/size/body
enlarged heart ( J:218247 )
• at E17.5 and P0




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory