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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Snrktm2Rra
targeted mutation 2, Ramani Ramchandran
MGI:5792703
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Snrktm2Rra/Snrktm2Rra
Tg(Tek-cre)1Ywa/0 		involves: C57BL/6 * C57BL/6J * SJL MGI:5792712
cn2
 		Snrktm2Rra/Snrktm2Rra
Tg(Myh6-cre)2182Mds/0 		involves: C57BL/6J * FVB/N MGI:5792710
cn3
 		Snrktm2Rra/Snrk+
Tg(Myh6-cre)2182Mds/0 		involves: C57BL/6J * FVB/N MGI:5792711


Genotype
MGI:5792712
cn1
Allelic
Composition		 Snrktm2Rra/Snrktm2Rra
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snrktm2Rra mutation (0 available); any Snrk mutation (37 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5792710
cn2
Allelic
Composition		 Snrktm2Rra/Snrktm2Rra
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snrktm2Rra mutation (0 available); any Snrk mutation (37 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:218247 )
N
• mice do not exhibit neonatal lethality unlike knock-out mice
premature death ( J:218247 )
• mice die between 8 to 10 months of age

cardiovascular system
cardiovascular system phenotype ( J:218247 )
N
• mice exhibit normal stroke volume, left ventricle mass and heart rate
abnormal heart left ventricle morphology ( J:218247 )
• enlarged left ventricle inner diameter in systole and diastole
• increased end diastolic and end systolic volume
decreased heart left ventricle muscle contractility ( J:218247 )
• decreased ejection fraction and fractional shortening in the left ventricle

homeostasis/metabolism
abnormal lipid level ( J:218247 )
• neonatal hearts exhibit increased staining for neutral lipids using oil red O (ORO)

muscle
decreased heart left ventricle muscle contractility ( J:218247 )
• decreased ejection fraction and fractional shortening in the left ventricle




Genotype
MGI:5792711
cn3
Allelic
Composition		 Snrktm2Rra/Snrk+
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snrktm2Rra mutation (0 available); any Snrk mutation (37 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:218247 )
• mice die shortly after one year of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory