Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Trim72)1Rpx
• Allele Name: transgene insertion 1, Rui-Ping Xiao
• Allele ID: MGI:5792805
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-Trim72)1Rpx/0	C57BL/6-Tg(Myh6-Trim72)1Rpx	MGI:5792807

Genotype
MGI:5792807

tg1

• Allelic Composition: Tg(Myh6-Trim72)1Rpx/0
• Genetic Background: C57BL/6-Tg(Myh6-Trim72)1Rpx

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart morphology ( J:234132 )

• lipid deposition in the heart

enlarged heart ( J:234132 )

• 20 week old mice exhibit enlarged hearts

myocardium hypertrophy ( J:234132 )

• myocardial hypertrophy as evidenced by increased ratio of heart weight to tibia length and gene expression analysis

increased heart weight ( J:234132 )

• weight of hearts is increased by 15%

abnormal heart left ventricle morphology ( J:234132 )

• enlarged left ventricular inner diameter with reduced posterior wall thickness

dilated heart ventricle ( J:234132 )

• the interventricular inner diameter is increased by 22%

cardiac fibrosis ( J:234132 )

• myocardial fibrosis

decreased cardiac muscle contractility ( J:234132 )

• mice show suppressed ejection fraction and fractional shortening

abnormal myocardial fiber physiology ( J:234132 )

• oxygen consumption rate of cardiomyocytes is elevated, indicating that the heart consumes more free fatty acids

cardiomyopathy ( J:234132 )

• diabetic cardiomyopathy

muscle

myocardium hypertrophy ( J:234132 )

• myocardial hypertrophy as evidenced by increased ratio of heart weight to tibia length and gene expression analysis

decreased cardiac muscle contractility ( J:234132 )

• mice show suppressed ejection fraction and fractional shortening

cardiomyopathy ( J:234132 )

• diabetic cardiomyopathy

growth/size/body

enlarged heart ( J:234132 )

• 20 week old mice exhibit enlarged hearts

myocardium hypertrophy ( J:234132 )

• myocardial hypertrophy as evidenced by increased ratio of heart weight to tibia length and gene expression analysis

increased heart weight ( J:234132 )

• weight of hearts is increased by 15%