Phenotypes associated with this allele

• Allele Symbol: Esyt3^{tm1d(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1d, Wellcome Trust Sanger Institute
• Allele ID: MGI:5792823
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Esyt3^tm1d(EUCOMM)Wtsi/Esyt3^tm1d(EUCOMM)Wtsi	involves: C57BL/6N	MGI:5896574
cx2	Esyt2^Gt(AN0678)Wtsi/Esyt2^Gt(AN0678)Wtsi Esyt3^tm1d(EUCOMM)Wtsi/Esyt3^tm1d(EUCOMM)Wtsi	involves: 129P2/OlaHsd * C57BL/6N	MGI:5896572

Genotype
MGI:5896574

hm1

• Allelic Composition: Esyt3^{tm1d(EUCOMM)Wtsi}/Esyt3^{tm1d(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0458_5_A10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:232605 )

• mice are viable and fertile without overt morphological defects

Genotype
MGI:5896572

cx2

• Allelic Composition: Esyt2^{Gt(AN0678)Wtsi}/Esyt2^{Gt(AN0678)Wtsi}; Esyt3^{tm1d(EUCOMM)Wtsi}/Esyt3^{tm1d(EUCOMM)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N
• Cell Lines: EPD0458_5_A10

mortality/aging

prenatal lethality, incomplete penetrance ( J:232605 )

• fewer than expected mice are born

• however, surviving mice exhibit normal development, viability, survival, reproduction and organ development (lung, testis and spleen)

cellular

increased sensitivity to induced cell death ( J:232605 )

• mouse embryonic fibroblasts are less resistance to FGF serum withdrawal compared with control cells

increased cellular sensitivity to oxidative stress ( J:232605 )

• in mouse embryonic fibroblasts

decreased cell migration ( J:232605 )

• of FGF-stimulated mouse embryonic fibroblasts