Phenotypes associated with this allele

• Allele Symbol: Nprl2^tm1.2Bpt
• Allele Name: targeted mutation 1.2, Benjamine P Tu
• Allele ID: MGI:5792912
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nprl2^tm1.2Bpt/Nprl2^tm1.2Bpt	involves: C57BL/6	MGI:5792944

Genotype
MGI:5792944

hm1

• Allelic Composition: Nprl2^tm1.2Bpt/Nprl2^tm1.2Bpt
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:224837 )

N • 20 week old mice exhibit normal blood counts

abnormal erythropoiesis ( J:224837 )

• impaired

impaired hematopoiesis ( J:224837 )

• in the fetal liver

decreased erythroid progenitor cell number ( J:224837 )

• reduced CFU-e and BFU-e from E12.5 livers

decreased hematopoietic precursor cell number ( J:224837 )

• reduced in the liver

vision/eye

microphthalmia ( J:224837 )

anophthalmia ( J:224837 )

• occasionally unilateral

growth/size/body

decreased embryo size ( J:224837 )

• at E12.5

homeostasis/metabolism

abnormal amino acid metabolism ( J:224837 )

• reduced methionine and elevated 5-methyltetrahydrofolate at E12.5 suggesting defective methionine synthase

• reduced leucine, isoleucine and glutamine levels at E12.5

liver/biliary system

pale liver ( J:224837 )

embryo

decreased embryo size ( J:224837 )

• at E12.5