Phenotypes associated with this allele

• Allele Symbol: Lrrc52^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5792928
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrrc52^tm1.1(KOMP)Vlcg/Lrrc52^tm1.1(KOMP)Vlcg	C57BL/6-Lrrc52^tm1.1(KOMP)Vlcg	MGI:5896617
cx2	Catsper1^tm1Clph/Catsper1^tm1Clph Lrrc52^tm1.1(KOMP)Vlcg/Lrrc52^tm1.1(KOMP)Vlcg	involves: 129S4/SvJae * C57BL/6NTac	MGI:5896618

Genotype
MGI:5896617

hm1

• Allelic Composition: Lrrc52^{tm1.1(KOMP)Vlcg}/Lrrc52^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6-Lrrc52^{tm1.1(KOMP)Vlcg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reduced male fertility ( J:220171 )

♂ • IVF success is markedly reduced but not as bad as in mice homozygous for Kcnu1^tm1.2Clin

impaired fertilization ( J:220171 )

♂ • IVF success is markedly reduced but not as bad as in mice homozygous for Kcnu1^tm1.2Clin

abnormal sperm physiology ( J:220171 )

♂ • in corpus epididymal sperm activation of KSPER currents is shifted to positive voltages

♂ • impaired alkaline pH induced hyperpolarization

Genotype
MGI:5896618

cx2

• Allelic Composition: Catsper1^tm1Clph/Catsper1^tm1Clph; Lrrc52^{tm1.1(KOMP)Vlcg}/Lrrc52^{tm1.1(KOMP)Vlcg}
• Genetic Background: involves: 129S4/SvJae * C57BL/6NTac

reproductive system

abnormal sperm physiology ( J:220171 )

♂ • maximal peak conductances measured at +200 mV at pH 8 are 6.1+/- 0.7 nS