All Phenotypes P2ry2<tm1c(EUCOMM)Hmgu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

P2ry2^{tm1c(EUCOMM)Hmgu}
targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI:5792951

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	P2ry2^{tm1c(EUCOMM)Hmgu}/P2ry2^{tm1c(EUCOMM)Hmgu} Tg(Tek-icre/ERT2)1Soff/0	B6N.Cg-P2ry2^{tm1c(EUCOMM)Hmgu} Tg(Tek-icre/ERT2)1Soff	MGI:5800452

Allelic Composition	P2ry2^{tm1c(EUCOMM)Hmgu}/P2ry2^{tm1c(EUCOMM)Hmgu} Tg(Tek-icre/ERT2)1Soff/0
Genetic Background	B6N.Cg-P2ry2^{tm1c(EUCOMM)Hmgu} Tg(Tek-icre/ERT2)1Soff
Cell Lines	HEPD0557_7_B07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2ry2^{tm1c(EUCOMM)Hmgu} mutation (0 available); any P2ry2 mutation (18 available)
Tg(Tek-icre/ERT2)1Soff mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased susceptibility to hypertension ( J:224523 )

decreased vasodilation ( J:224523 )

• almost complete lost of dilation in response to flow

• however, vasodilation in response to sodium nitroprusside and vasoconstriction in response to phenylephrine are normal

muscle

decreased vasodilation ( J:224523 )

• almost complete lost of dilation in response to flow

• however, vasodilation in response to sodium nitroprusside and vasoconstriction in response to phenylephrine are normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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