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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Dmp1-cre/ERT2)0022Pdp
transgene insertion 0022, Paola Divieti Pajevic
MGI:5792965
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Pth1rtm2Hmk/Pth1rtm2Hmk
Tg(Dmp1-cre/ERT2)0022Pdp/0
involves: 129S4/SvJae * C3H * C57BL/6 MGI:5297558


Genotype
MGI:5297558
cn1
Allelic
Composition
Pth1rtm2Hmk/Pth1rtm2Hmk
Tg(Dmp1-cre/ERT2)0022Pdp/0
Genetic
Background
involves: 129S4/SvJae * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm2Hmk mutation (0 available); any Pth1r mutation (29 available)
Tg(Dmp1-cre/ERT2)0022Pdp mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
N
• tamoxifen-treated adult mice have relatively normal rates of bone modeling and remodeling
• vertebral bone mineral density is signifiincantly reduced in tamoxifen-treated adult females; a similar trend is observed in males but is not statistically significant
• femoral bone mineral density is signifiincantly reduced in tamoxifen-treated adult females; a similar trend is observed in males but is not statistically significant
• tibia of tamoxifen-treated adult mice exhibit reduction in trabecular bone and a delay in the secondary ossification center





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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory