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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Phlpp2tm1d(EUCOMM)Hmgu
targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH
MGI:5795604
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Phlpp2tm1d(EUCOMM)Hmgu/Phlpp2tm1d(EUCOMM)Hmgu involves: C57BL/6N MGI:5795608
cx2
 		Phlpp1tm1.1Saco/Phlpp1tm1.1Saco
Phlpp2tm1d(EUCOMM)Hmgu/Phlpp2tm1d(EUCOMM)Hmgu 		involves: 129 * C57BL/6N MGI:5795607


Genotype
MGI:5795608
hm1
Allelic
Composition		 Phlpp2tm1d(EUCOMM)Hmgu/Phlpp2tm1d(EUCOMM)Hmgu
Genetic
Background		 involves: C57BL/6N
Cell Lines HEPD0619_1_C08
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phlpp2tm1d(EUCOMM)Hmgu mutation (0 available); any Phlpp2 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:231241 )
N
• mice exhibit normal susceptibility to DSS-induced colitis

immune system
immune system phenotype ( J:231241 )
N
• mice exhibit normal susceptibility to DSS-induced colitis




Genotype
MGI:5795607
cx2
Allelic
Composition		 Phlpp1tm1.1Saco/Phlpp1tm1.1Saco
Phlpp2tm1d(EUCOMM)Hmgu/Phlpp2tm1d(EUCOMM)Hmgu
Genetic
Background		 involves: 129 * C57BL/6N
Cell Lines HEPD0619_1_C08
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phlpp1tm1.1Saco mutation (0 available); any Phlpp1 mutation (52 available)
Phlpp2tm1d(EUCOMM)Hmgu mutation (0 available); any Phlpp2 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
decreased susceptibility to induced colitis ( J:231241 )
• DSS-treated mice exhibit reduced weight loss, colonic epithelial damage or crypt damage, macrophage infiltration, epithelial cell apoptosis and reduction in colon length compared with wild-type mice

growth/size/body
decreased susceptibility to weight loss ( J:231241 )
• in DSS-treated mice

immune system
decreased susceptibility to induced colitis ( J:231241 )
• DSS-treated mice exhibit reduced weight loss, colonic epithelial damage or crypt damage, macrophage infiltration, epithelial cell apoptosis and reduction in colon length compared with wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory