About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ctnnbl1tm1.1Crad
targeted mutation 1.1, Cristina Rada
MGI:5795658
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ctnnbl1tm1.1Crad/Ctnnbl1tm1.1Crad involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5795707
cn2
 		Cd79atm1(cre)Reth/Cd79a+
Ctnnbl1tm1.1Crad/Ctnnbl1tm1.1Crad 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL MGI:5795709
cn3
 		Cd19tm1(cre)Cgn/Cd19+
Ctnnbl1tm1.1Crad/Ctnnbl1tm1.1Crad 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5795711


Genotype
MGI:5795707
hm1
Allelic
Composition		 Ctnnbl1tm1.1Crad/Ctnnbl1tm1.1Crad
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnbl1tm1.1Crad mutation (0 available); any Ctnnbl1 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:232010 )
N
• mice are viable




Genotype
MGI:5795709
cn2
Allelic
Composition		 Cd79atm1(cre)Reth/Cd79a+
Ctnnbl1tm1.1Crad/Ctnnbl1tm1.1Crad
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Ctnnbl1tm1.1Crad mutation (0 available); any Ctnnbl1 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:232010 )
N
• mice exhibit normal splenic B cells numbers and early stages of B cell differentiation
abnormal B cell proliferation ( J:232010 )
• delayed entry into S phase on activation of resting, affecting follicular more than marginal zone B cells
decreased B cell proliferation ( J:232010 )
• in response to LPS or anti-CD40 stimulation
abnormal class switch recombination ( J:232010 )
• reduced immunoglobin class switching in splenic B cells

hematopoietic system
abnormal B cell proliferation ( J:232010 )
• delayed entry into S phase on activation of resting, affecting follicular more than marginal zone B cells
decreased B cell proliferation ( J:232010 )
• in response to LPS or anti-CD40 stimulation
abnormal class switch recombination ( J:232010 )
• reduced immunoglobin class switching in splenic B cells

cellular
abnormal B cell proliferation ( J:232010 )
• delayed entry into S phase on activation of resting, affecting follicular more than marginal zone B cells
decreased B cell proliferation ( J:232010 )
• in response to LPS or anti-CD40 stimulation




Genotype
MGI:5795711
cn3
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Ctnnbl1tm1.1Crad/Ctnnbl1tm1.1Crad
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (57 available)
Ctnnbl1tm1.1Crad mutation (0 available); any Ctnnbl1 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell proliferation ( J:232010 )
• in response to LPS or anti-CD40 stimulation

immune system
decreased B cell proliferation ( J:232010 )
• in response to LPS or anti-CD40 stimulation

cellular
decreased B cell proliferation ( J:232010 )
• in response to LPS or anti-CD40 stimulation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory