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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ctnnbl1tm1.1Crad
targeted mutation 1.1, Cristina Rada
MGI:5795658
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ctnnbl1tm1.1Crad/Ctnnbl1tm1.1Crad involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5795707
cn2
 		Cd79atm1(cre)Reth/Cd79a+
Ctnnbl1tm1.1Crad/Ctnnbl1tm1.1Crad 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL MGI:5795709
cn3
 		Cd19tm1(cre)Cgn/Cd19+
Ctnnbl1tm1.1Crad/Ctnnbl1tm1.1Crad 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5795711


Genotype
MGI:5795707
hm1
Allelic
Composition		 Ctnnbl1tm1.1Crad/Ctnnbl1tm1.1Crad
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnbl1tm1.1Crad mutation (0 available); any Ctnnbl1 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:232010 )
N
• mice are viable




Genotype
MGI:5795709
cn2
Allelic
Composition		 Cd79atm1(cre)Reth/Cd79a+
Ctnnbl1tm1.1Crad/Ctnnbl1tm1.1Crad
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Ctnnbl1tm1.1Crad mutation (0 available); any Ctnnbl1 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:232010 )
N
• mice exhibit normal splenic B cells numbers and early stages of B cell differentiation
abnormal B cell proliferation ( J:232010 )
• delayed entry into S phase on activation of resting, affecting follicular more than marginal zone B cells
decreased B cell proliferation ( J:232010 )
• in response to LPS or anti-CD40 stimulation
abnormal class switch recombination ( J:232010 )
• reduced immunoglobin class switching in splenic B cells

hematopoietic system
abnormal B cell proliferation ( J:232010 )
• delayed entry into S phase on activation of resting, affecting follicular more than marginal zone B cells
decreased B cell proliferation ( J:232010 )
• in response to LPS or anti-CD40 stimulation
abnormal class switch recombination ( J:232010 )
• reduced immunoglobin class switching in splenic B cells

cellular
abnormal B cell proliferation ( J:232010 )
• delayed entry into S phase on activation of resting, affecting follicular more than marginal zone B cells
decreased B cell proliferation ( J:232010 )
• in response to LPS or anti-CD40 stimulation




Genotype
MGI:5795711
cn3
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Ctnnbl1tm1.1Crad/Ctnnbl1tm1.1Crad
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Ctnnbl1tm1.1Crad mutation (0 available); any Ctnnbl1 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell proliferation ( J:232010 )
• in response to LPS or anti-CD40 stimulation

immune system
decreased B cell proliferation ( J:232010 )
• in response to LPS or anti-CD40 stimulation

cellular
decreased B cell proliferation ( J:232010 )
• in response to LPS or anti-CD40 stimulation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory