Analysis Tools
mortality/aging
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• fewer than expected mice are present between E15.5 and E17.5 with no mice detected at E18.5
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nervous system
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• in the neuroepithelium at E9.5 but not E8.5
|
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• increased cellular numbers in the hindbrain
• increased thickness in the mid- and forebrain
|
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• at E9.5, mice exhibit large open anterior neural tube encompassing the mid and hindbrain with some extension into the forebrain region
• mice exhibit a failure of the dorsolateral hinge formation and neural tube closure with collapse of the neural fold by E10.5
|
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• severe
• however, anterior-posterior patterning is normal
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exencephaly
(
J:232516
)
|
• in hindbrains at E13.5
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• at E8.5 but not E9.5
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embryo
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• abnormal embryo at E9.5
• however, mice are normal at E7.5
|
|
• increased cellular numbers in the hindbrain
• increased thickness in the mid- and forebrain
|
|
• at E9.5, mice exhibit large open anterior neural tube encompassing the mid and hindbrain with some extension into the forebrain region
• mice exhibit a failure of the dorsolateral hinge formation and neural tube closure with collapse of the neural fold by E10.5
|
cellular
|
• in the neuroepithelium at E9.5 but not E8.5
|
