Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Bglap2-TAg)1Rkho transgene insertion 1, Rama Khokha MGI:5796023 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• tumor onset, survival, tumor burden, and lung metastasis is comparable to single Tg(Bglap2-TAg)1Rkho hemizygous mice
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• tumor onset, survival, tumor burden, and lung metastasis is comparable to single Tg(Bglap2-TAg)1Rkho hemizygous mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Prkar1a heterozygosity accelerates osteosarcoma development in Tg(Bglap2-TAg)1Rkho/0 mice
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• no mice survive past 5 weeks of age
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• mice develop advanced osteosarcoma, often in the spine
• mice exhibit multi-ostotic tumors in long and flat bones, including the skull, vertebrae, ribs, and tibia
• however, metastasis is not seen at this early age
• tumors show increased osteoclast numbers
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• mice develop advanced osteosarcoma, often in the spine
• mice exhibit multi-ostotic tumors in long and flat bones, including the skull, vertebrae, ribs, and tibia
• however, metastasis is not seen at this early age
• tumors show increased osteoclast numbers
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• impaired mobility due to osteosarcoma in the spine
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit suppression of osteosarcoma development with only 2 of 35 mice showing tumors
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• femurs from 42 week old mice show only benign parosteal growths without evidence of malignant cells
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• femurs from 42 week old mice show only benign parosteal growths without evidence of malignant cells
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• mice exhibit suppression of osteosarcoma development with only 2 of 35 mice showing tumors
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit the same tumor incidence, burden and survival as single Tg(Bglap2-TAg)1Rkho hemizygous mice
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• mice exhibit the same tumor incidence, burden and survival as single Tg(Bglap2-TAg)1Rkho hemizygous mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Poorly calcified femur tumor with bone destruction in a Tg(Bglap2-TAg)1Rkho/0 mouse
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• mice die after 21 weeks of age due to tumors
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• spontaneous metastases are seen in the lungs of more than 90% of mice at time of morbidity, and less frequently in the liver and occasionally in the kidney and spleen
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• mice form multi-ostotic bone tumors with complete penetrance at a young age and showing varying levels of calcification
• skeletal tumors show a peak incidence in the long bones and a higher prevalence of craniofacial tumors
• tumors exhibit increased osteoclast numbers
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• mice develop a spectrum of osteoblastic lesions from benign osteoma to aggressive metastatic osteosarcoma, with most being osteoblastic osteosarcoma, with features typical of high-grade osteosarcoma
• osteosarcomas are genomically unstable
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• mice form multi-ostotic bone tumors with complete penetrance at a young age and showing varying levels of calcification
• skeletal tumors show a peak incidence in the long bones and a higher prevalence of craniofacial tumors
• tumors exhibit increased osteoclast numbers
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• mice develop a spectrum of osteoblastic lesions from benign osteoma to aggressive metastatic osteosarcoma, with most being osteoblastic osteosarcoma, with features typical of high-grade osteosarcoma
• osteosarcomas are genomically unstable
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| osteosarcoma | DOID:3347 |
OMIM:259500 |
J:165282 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 50% of mice survive to 26 weeks of age
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• mice develop aggressive osteosarcoma with complete penetrance
• treatment of mice with RANK-Fc beginning at 17 weeks of age suppresses osteosarcoma progression and reduces lung metastasis by more than 3-fold
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• mice develop aggressive osteosarcoma with complete penetrance
• treatment of mice with RANK-Fc beginning at 17 weeks of age suppresses osteosarcoma progression and reduces lung metastasis by more than 3-fold
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| osteosarcoma | DOID:3347 |
OMIM:259500 |
J:234128 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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