Phenotypes associated with this allele

• Allele Symbol: Pten^tm1.1Jaes
• Allele Name: targeted mutation 1.1, Jose A Esteban
• Allele ID: MGI:5796481
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pten^tm1.1Jaes/Pten^tm1.1Jaes	B6.129S6(FVB)-Pten^tm1.1Jaes	MGI:5796797

Genotype
MGI:5796797

hm1

• Allelic Composition: Pten^tm1.1Jaes/Pten^tm1.1Jaes
• Genetic Background: B6.129S6(FVB)-Pten^tm1.1Jaes

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal CNS synaptic transmission ( J:234430 )

• expression of an App gene carrying the Swedish and London mutations using a viral expression system (for neuronal production of amyloid beta) in neurons from mutants does not depress AMPAR-mediated synaptic transmission as it does in wild-type neurons

• mice exhibit normal basal synaptic transmission in hippocampal slices, and normal LTP, even in the presence of amyloid beta 42 assemblies

abnormal synaptic depression ( J:234430 )

• hippocampal slices treated with 1 uM synthetic amyloid beta 42 assemblies are resistant to amyloid beta treatment and do not show amyloid beta-triggered synaptic depression as seen in wild-type slices

• hippocampal slices fail to show induction of long term depression (LTD) with an NMDAR-dependent protocol under partial NMDAR blockade and there is no facilitation of LTD following amyloid beta treatment