Phenotypes associated with this allele

• Allele Symbol: Sh3pxd2b^tm1.1Arte
• Allele Name: targeted mutation 1.1, TaconicArtemis
• Allele ID: MGI:5800300
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sh3pxd2b^tm1.1Arte/Sh3pxd2b^tm1.1Arte	involves: C57BL/6NTac	MGI:5800322

Genotype
MGI:5800322

hm1

• Allelic Composition: Sh3pxd2b^tm1.1Arte/Sh3pxd2b^tm1.1Arte
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

infertility ( J:235640 )

adipose tissue

decreased subcutaneous adipose tissue amount ( J:235640 )

abnormal adipose tissue development ( J:235640 )

• mesenchymal stromal cells exhibit reduced adipogenic potential compared with wild-type cells

decreased body fat mass ( J:235640 )

• increased total, subcutaneous, gonadal, intestinal, and perirenal white adipose tissue

decreased gonadal fat pad weight ( J:235640 )

decreased renal fat pad weight ( J:235640 )

lipodystrophy ( J:235640 )

skeleton

decreased length of long bones ( J:235640 )

short femur ( J:235640 )

short tibia ( J:235640 )

kyphosis ( J:235640 )

abnormal skeleton development ( J:235640 )

• mesenchymal stromal cells exhibit reduced ability to differentiate into osteogenic lineage compared with wild-type cells

large anterior fontanelle ( J:235640 )

growth/size/body

decreased body fat mass ( J:235640 )

• increased total, subcutaneous, gonadal, intestinal, and perirenal white adipose tissue

decreased body size ( J:235640 )

decreased body weight ( J:235640 )

vision/eye

exophthalmos ( J:235640 )

• prominent eyes

craniofacial

abnormal craniofacial morphology ( J:235640 )

large anterior fontanelle ( J:235640 )

integument

decreased subcutaneous adipose tissue amount ( J:235640 )

limbs/digits/tail

short femur ( J:235640 )

short tibia ( J:235640 )