All Phenotypes Shank3<tm2.2Yhj> MGI Mouse

nervous system phenotype ( J:235641 )

N	• mice do not exhibit spontaneous seizures

abnormal brain white matter morphology ( J:235641 )

• reduced relative to grey matter

abnormal brain commissure morphology ( J:235641 )

• all five white matter tracts except the fornix exhibit reduced volume compared with wild-type mice

abnormal brain internal capsule morphology ( J:235641 )

• unilateral change

abnormal cerebellar peduncle morphology ( J:235641 )

• reduced

abnormal cingulum morphology ( J:235641 )

• reduced

abnormal basal ganglion morphology ( J:235641 )

• enlarged

thalamus hyperplasia ( J:235641 )

decreased amygdala size ( J:235641 )

small hippocampus ( J:235641 )

abnormal olfactory lobe morphology ( J:235641 )

• decreased size

abnormal spinal cord commissure morphology ( J:235641 )

• reduced spinal trigeminal tract

abnormal dendritic spine morphology ( J:235641 )

• decreased spine density on motor sensory neurons and striatum compared with wild-type mice

• however, spine density is normal in the hippocampus

abnormal synapse morphology ( J:235641 )

• decreased glutamatergic synapses compared with wild-type mice

• shorter and thinner striatal synapses compared with wild-type mice

abnormal nervous system electrophysiology ( J:235641 )

• altered functional connectivity in a frontostriatal circuit

abnormal single cell response ( J:235641 )

• motor sensory neurons exhibit enhanced excitability compared with wild-type mice

• however, treatment with a Grm5 positive allosteric modulate (CDPPB) rescues hyper-excitability

decreased excitatory postsynaptic current frequency ( J:235641 )

• reduced frequency in motor sensory neurons compared with wild-type mice

• treatment with a Grm5 positive allosteric modulate (CDPPB) does not change the frequency or amplitude of sEPSCs

reduced long-term depression ( J:235641 )

• following high-frequency stimulation

• however, treatment with a Grm5 positive allosteric modulate (CDPPB) rescues LTD without altering the probability of presynaptic release

abnormal behavior ( J:235641 )

• mice fail to show preference for a home nest versus an unfamiliar nest compared with wild-type mice

enhanced contextual conditioning behavior ( J:235641 )

• small enhancement

• however, mice exhibit normal cured conditioning

abnormal response to new environment ( J:235641 )

• in an arena for the novel object recognition memory test, in a novel larger arena or Morris water maze, mice try to escape the test chamber unlike wild-type mice

• however, mice placed into clean home cages do not try to escape

impaired learning ( J:235641 )

• impaired striatal learning in a bar-press food task

• however, treatment with a Grm5 positive allosteric modulate (CDPPB) partially rescues instrumental learning

impaired spatial learning ( J:235641 )

• impaired reverse learning in a Morris water maze

• however, mice exhibit normal acquisition performance in a Morris water maze and normal swimming

increased anxiety-related response ( J:235641 )

• mice spend less time in the center of the open field compared with wild-type mice

• in a light-dark emergence test, mice exhibit delayed entry into the lighted chamber and made fewer transitions between chambers compared with wild-type mice

increased grooming behavior ( J:235641 )

• mice engage in fewer of the 16 holes in a hole-board test with a tendency to re-investigate the same hole compared with wild-type mice

• mice exhibit increased grooming during social investigation tests compared with wild-type mice

• treatment with a Grm5 positive allosteric modulate (CDPPB) increases self-grooming

• however, treatment with a Grm5 antagonist (MPEP) normalizes grooming

increased startle reflex ( J:235641 )

impaired coordination ( J:235641 )

• on an accelerating and steady-speed rotarods despite normal grip strength

decreased locomotor activity ( J:235641 )

• in home cage and an open field with a tendency toward decreased rearing

• however, treatment with a Grm5 antagonist (MPEP) normalizes activity in an open field

abnormal social/conspecific interaction behavior ( J:235641 )

• mice fail to establish stable hierarchies unlike wild-type mice

abnormal social investigation ( J:235641 )

• mice exhibit longer and more frequent non-reciprocal social investigation behavior with C3H mice compared with wild-type mice

• however, mice exhibit normal levels of social interest

decreased vocalization ( J:235641 )

• fewer and shorter duration compared with wild-type mice

• lower frequencies and amplitudes of calls compared with wild-type mice

• male mice emit fewer calls with shorter duration and reduced amplitude compared with wild-type mice

• however, peak frequency is normal

abnormal ear development ( J:235641 )

• delayed ear opening at P4

skin lesions ( J:235641 )

• in 16 of 30 mice at 5.5 months around the eyes, on the ears, back of the head, and under the chin of mice caused by excessive grooming

abnormal autopod morphology ( J:235641 )

• delayed paw position at P4

abnormal odor adaptation ( J:235641 )

• mice exhibit less robust habituation-dishabituation to olfactory stimuli compared with wild-type mice

• however, mice exhibit normal sniffing a social stimulus

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24