Phenotypes associated with this allele

• Allele Symbol: Sik3^Slp
• Allele Name: sleepy
• Allele ID: MGI:5800458
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sik3^Slp/Sik3^Slp	involves: C57BL/6J * C57BL/6N	MGI:5806618
ht2	Sik3^Slp/Sik3^+	involves: C57BL/6J * C57BL/6N	MGI:5806616

Genotype
MGI:5806618

hm1

• Allelic Composition: Sik3^Slp/Sik3^Slp
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:236598 )

N • under constant darkness, mice exhibit normal circadian period

abnormal sleep duration ( J:236598 )

• prolonged sleep time and shorter daily wake times, more so than in heterozygotes

• mice exhibit prominent wake responses to cage change, caffeine or modafinil

abnormal non-rapid eye movement sleep pattern ( J:236598 )

• increased non-rapid eye movement sleep (NREMS) time in both the light and dark phases, more so than in heterozygotes

• higher NREMS to total sleep ratio than in wild-type mice

• mice exhibit increased non-rapid eye movement sleep delta (slow-wave activity) density compared with wild-type mice

abnormal paradoxical sleep pattern ( J:236598 )

• lower rapid eye movement sleep (REMS) to total sleep ratio compared with wild-type mice

• longer time spent in REMS during the dark phase secondary to increased sleep amount and shorter REMS time during the light phase

nervous system

abnormal brain wave pattern ( J:236598 )

• mice exhibit increased non-rapid eye movement sleep delta (slow-wave activity) density compared with wild-type mice

Genotype
MGI:5806616

ht2

• Allelic Composition: Sik3^Slp/Sik3⁺
• Genetic Background: involves: C57BL/6J * C57BL/6N

behavior/neurological

abnormal circadian sleep/wake cycle ( J:236598 )

• under constant darkness, mice exhibit reduced wake time compared with wild-type mice

• however, mice exhibit normal period

abnormal sleep duration ( J:236598 )

• prolonged sleep time and shorter daily wake times

• hypersomnia is more pronounced in the dark phase

• mice exhibit prominent wake responses to cage change, caffeine or modafinil

abnormal non-rapid eye movement sleep pattern ( J:236598 )

• increased non-rapid eye movement sleep (NREMS) time in both the light and dark phases, more so than in heterozygotes

• higher NREMS to total sleep ratio than in wild-type mice

• mice exhibit increased NREMS delta (slow-wave activity) density compared with wild-type mice

• 6 hours of sleep deprivation from the onset of the light phase increased non-rapid eye movement sleep (NREMS) delta power to a larger extent compared with wild-type mice

abnormal paradoxical sleep pattern ( J:236598 )

• lower rapid eye movement sleep (REMS) to total sleep ratio compared with wild-type mice

• longer time spent in REMS during the dark phase secondary to increased sleep amount and shorter REMS time during the light phase

nervous system

abnormal brain wave pattern ( J:236598 )

• after 6 hours of sleep deprivation, mice exhibit increased normal relative increase in delta power compared with wild-type mice

• mice exhibit increased non-rapid eye movement sleep delta (slow-wave activity) density compared with wild-type mice

• 6 hours of sleep deprivation from the onset of the light phase increased non-rapid eye movement sleep (NREMS) delta power to a larger extent compared with wild-type mice

• however, mice exhibit a normal relative increase in delta power after 2 or 4 hours sleep deprivation