Analysis Tools
growth/size/body
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• lower body weight in old mice
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homeostasis/metabolism
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• mice exhibit accumulation of amyloid beta plaques with age, first seen in the cerebral cortex at 8 months of age and then in the hippocampus between 10-12.5 months of age
• plaques include both dense-core and diffuse types and comparable plaque loads are seen in the cortex and hippocampus
• mice show an age-dependent increase in the production of amyloid beta 38, 40 and 42 in the brain, with more than 90% of amyloid beta 40 building the dense cores of plaques, and amyloid beta 42 being the main component of diffuse plaques and loosely core-associated oligomers
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nervous system
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• mice exhibit accumulation of amyloid beta plaques with age, first seen in the cerebral cortex at 8 months of age and then in the hippocampus between 10-12.5 months of age
• plaques include both dense-core and diffuse types and comparable plaque loads are seen in the cortex and hippocampus
• mice show an age-dependent increase in the production of amyloid beta 38, 40 and 42 in the brain, with more than 90% of amyloid beta 40 building the dense cores of plaques, and amyloid beta 42 being the main component of diffuse plaques and loosely core-associated oligomers
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• mutants exhibit reduced forebrain weight compared to non-transgenic mice but similar in weight to single Tg(Camk2a-tTA)Mmay expressing mice
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• mutants exhibit decreased dentate gyrus size compared to non-transgenic mice but size is similar to that seen in single Tg(Camk2a-tTA)Mmay expressing mice
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• mice exhibit aggravated axonal curvature and swollen, dystrophic neurites surrounding plaques
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:235351 | ||
