All Phenotypes Ccdc59<em1(IMPC)J> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccdc59^em1(IMPC)J/Ccdc59^em1(IMPC)J	C57BL/6NJ-Ccdc59^em1(IMPC)J/J	MGI:6262049
ht2	Ccdc59^em1(IMPC)J/Ccdc59⁺	C57BL/6NJ-Ccdc59^em1(IMPC)J/J	MGI:6262048

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Ccdc59^em1(IMPC)J/Ccdc59^em1(IMPC)J mice exhibit embryonic lethality, with no embryos seen at E9.5 and only a small percentage of necrotic embryos at E7.5. Embryos fail to gastrulate, are smaller, with absent egg cylinders, head folds, primitive node, and primitive streak formation at E7.5.

embryo

failure to gastrulate ( J:279207 )

• no morphological hallmarks typical of gastrulating embryos are observed at E7.5

embryonic growth arrest ( J:279207 )

• embryos arrest prior to gastrulation

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

absent egg cylinders ( J:279207 )

• no rudimentary egg cylinder is present at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

embryo tissue necrosis ( J:279207 )

• embryos appear as a necrotic mass of cells at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• only 6% of necrotic homozygous embryos are recovered at E7.5; no homozygous embryos are recovered at E9.5

Allelic Composition	Ccdc59^em1(IMPC)J/Ccdc59⁺
Genetic Background	C57BL/6NJ-Ccdc59^em1(IMPC)J/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccdc59^em1(IMPC)J mutation (1 available); any Ccdc59 mutation (11 available)

Data Sources

IMPC Data for Ccdc59

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased mean corpuscular volume ( J:211773 )

IMPC - JAX

vision/eye

cataract ( J:211773 )

IMPC - JAX

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24