All Phenotypes Lancl2<em1Vdd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lancl2^em1Vdd
endonuclease-mediated mutation 1, Wilfred van der Donk
MGI:5804215

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lancl2^em1Vdd/Lancl2^em1Vdd	FVB/N-Lancl2^em1Vdd	MGI:7580952
cx2	Lancl1^em1Vdd/Lancl1^em1Vdd Lancl2^em1Vdd/Lancl2^em1Vdd Lancl3^em1Vdd/Lancl3^em1Vdd	FVB/N-Lancl1^em1Vdd Lancl2^em1Vdd Lancl3^em1Vdd	MGI:6115294

Allelic Composition	Lancl2^em1Vdd/Lancl2^em1Vdd
Genetic Background	FVB/N-Lancl2^em1Vdd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lancl2^em1Vdd mutation (1 available); any Lancl2 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:249809 )

• mice are viable and fertile with no gross abnormalities

• lanthionine ketimine biosynthesis is not affected in mutant mice

Allelic Composition	Lancl1^em1Vdd/Lancl1^em1Vdd Lancl2^em1Vdd/Lancl2^em1Vdd Lancl3^em1Vdd/Lancl3^em1Vdd
Genetic Background	FVB/N-Lancl1^em1Vdd Lancl2^em1Vdd Lancl3^em1Vdd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lancl1^em1Vdd mutation (1 available); any Lancl1 mutation (21 available)
Lancl2^em1Vdd mutation (1 available); any Lancl2 mutation (24 available)
Lancl3^em1Vdd mutation (1 available); any Lancl3 mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:307075 )

• roughly 25%30% of KO mice died prematurely at ages between 2 and 6 months; surviving mice did not display any further phenotype

normal phenotype

no abnormal phenotype detected ( J:249809 )

• mice are viable and fertile with no gross abnormalities

• lanthionine ketimine biosynthesis is not affected in mutant mice

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