Phenotypes associated with this allele

• Allele Symbol: Neil2^tm1.1Tkhz
• Allele Name: targeted mutation 1.1, Tapas K Hazra
• Allele ID: MGI:5804531
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Neil2^tm1.1Tkhz/Neil2^tm1.1Tkhz	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl	MGI:5804537

Genotype
MGI:5804537

hm1

• Allelic Composition: Neil2^tm1.1Tkhz/Neil2^tm1.1Tkhz
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased telomere length ( J:225791 )

• higher frequency of undetectable telomere signal compared to in wild-type mouse embryonic fibroblasts

spontaneous chromosome breakage ( J:225791 )

• increased frequency of chromosomal aberrations in mouse embryonic cells

oxidative stress ( J:225791 )

• by 24 months, mice exhibit increased oxidized DNA damage with progression of age compared with wild-type mice

• however, DNA damage is minimal at 2 months of age

immune system

increased neutrophil cell number ( J:225791 )

• increased neutrophil infiltration following intranasal challenge with LPS, TNFa or glucose oxidase

lung inflammation ( J:225791 )

• increased neutrophil infiltration following intranasal challenge with LPS, TNFa or glucose oxidase

respiratory system

lung inflammation ( J:225791 )

• increased neutrophil infiltration following intranasal challenge with LPS, TNFa or glucose oxidase

hematopoietic system

increased neutrophil cell number ( J:225791 )

• increased neutrophil infiltration following intranasal challenge with LPS, TNFa or glucose oxidase