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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Faf2tm1Tfji
targeted mutation 1, Toyoshi Fujimoto
MGI:5805286
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Faf2tm1Tfji/Faf2tm1Tfji
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: C57BL/6 * C57BL/6N * CBA * DBA MGI:5805372


Genotype
MGI:5805372
cn1
Allelic
Composition
Faf2tm1Tfji/Faf2tm1Tfji
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background
involves: C57BL/6 * C57BL/6N * CBA * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faf2tm1Tfji mutation (0 available); any Faf2 mutation (24 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• mice fed a normal diet exhibit normal levels of alanine and aspartate transaminase and lactacte dehydrogenase
• mice fed a high-fat diet exhibit normal liver levels of triglyceride, total cholesterol and free cholesterol and insulin sensitivity
• 0.899-fold in females and 0.853-fold in males when mice are fed a high-fat diet
• in male mice when fed a normal diet
• in female mice when fed a normal diet
• 0.665-fold in females and 0.632-fold times in males when mice are fed a high-fat diet
• in mice fed a high-fat diet
• when mice are fed a high-fat diet
• 1.35-fold in females and 1/27-fold in males when fed a normal diet
• 2.23-fold in females and 1.52-fold in males when mice are fed a high-fat diet
• 1.74-fold in females and 1.30-fold in males when mice are fed a high-fat diet
• however, levels are normal in mice fed a normal diet
• reduced ApoB secretion from hepatocytes

liver/biliary system
• periportal macroscopic steatosis when mice are fed a high-fat diet, more so in female mice than male mice

growth/size/body
• 0.887-fold in females and 0.897-fold in males when mice are fed a high-fat diet





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory