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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prkd3tm1.1Shoy
targeted mutation 1.1, Sho Yamasaki
MGI:5805707
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0
Tg(TcraTcrb)425Cbn/0 		involves: 129 * BALB/c * C57BL/6 MGI:5805811
cn2
 		Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0 		involves: 129 * C57BL/6 MGI:5805806
cn3
 		Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0
Tg(TcraTcrb)1100Mjb/0 		involves: 129 * C57BL/6 MGI:5805812
cn4
 		Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0
Tg(TcraH-Y,TcrbH-Y)71Vbo/0 		involves: 129 * C57BL/6 * C57BL/6J * DBA/2J MGI:5805813
cn5
 		Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(BCL2)25Wehi/0
Tg(Lck-cre)1Jtak/0 		involves: 129 * C57BL/6 * C57BL/6JWehi * SJL/JWehi MGI:5805810


Genotype
MGI:5805811
cn1
Allelic
Composition		 Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0
Tg(TcraTcrb)425Cbn/0
Genetic
Background		 involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkd2tm1.1Shoy mutation (1 available); any Prkd2 mutation (41 available)
Prkd3tm1.1Shoy mutation (0 available); any Prkd3 mutation (62 available)
Tg(Lck-cre)1Jtak mutation (3 available)
Tg(TcraTcrb)425Cbn mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:236298 )
• CD4+ or CD8+ single positive thymocytes
• reduced CD4+CD8int intermediate cells

endocrine/exocrine glands
decreased thymocyte number ( J:236298 )
• CD4+ or CD8+ single positive thymocytes
• reduced CD4+CD8int intermediate cells

hematopoietic system
decreased thymocyte number ( J:236298 )
• CD4+ or CD8+ single positive thymocytes
• reduced CD4+CD8int intermediate cells




Genotype
MGI:5805806
cn2
Allelic
Composition		 Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkd2tm1.1Shoy mutation (1 available); any Prkd2 mutation (41 available)
Prkd3tm1.1Shoy mutation (0 available); any Prkd3 mutation (62 available)
Tg(Lck-cre)1Jtak mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
small thymus medulla ( J:236298 )
• small and fragmented
decreased thymocyte number ( J:236298 )
• reduced CD4+ single positive thymocytes
• reduced CD4+CD8int intermediate cells

endocrine/exocrine glands
small thymus medulla ( J:236298 )
• small and fragmented
decreased thymocyte number ( J:236298 )
• reduced CD4+ single positive thymocytes
• reduced CD4+CD8int intermediate cells

hematopoietic system
small thymus medulla ( J:236298 )
• small and fragmented
decreased thymocyte number ( J:236298 )
• reduced CD4+ single positive thymocytes
• reduced CD4+CD8int intermediate cells




Genotype
MGI:5805812
cn3
Allelic
Composition		 Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0
Tg(TcraTcrb)1100Mjb/0
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkd2tm1.1Shoy mutation (1 available); any Prkd2 mutation (41 available)
Prkd3tm1.1Shoy mutation (0 available); any Prkd3 mutation (62 available)
Tg(Lck-cre)1Jtak mutation (3 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:236298 )
• reduced CD4+CD8int intermediate cells

endocrine/exocrine glands
decreased thymocyte number ( J:236298 )
• reduced CD4+CD8int intermediate cells

hematopoietic system
decreased thymocyte number ( J:236298 )
• reduced CD4+CD8int intermediate cells




Genotype
MGI:5805813
cn4
Allelic
Composition		 Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkd2tm1.1Shoy mutation (1 available); any Prkd2 mutation (41 available)
Prkd3tm1.1Shoy mutation (0 available); any Prkd3 mutation (62 available)
Tg(Lck-cre)1Jtak mutation (3 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:236298 )
• CD8+ single positive thymocytes

endocrine/exocrine glands
decreased thymocyte number ( J:236298 )
• CD8+ single positive thymocytes

hematopoietic system
decreased thymocyte number ( J:236298 )
• CD8+ single positive thymocytes




Genotype
MGI:5805810
cn5
Allelic
Composition		 Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(BCL2)25Wehi/0
Tg(Lck-cre)1Jtak/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkd2tm1.1Shoy mutation (1 available); any Prkd2 mutation (41 available)
Prkd3tm1.1Shoy mutation (0 available); any Prkd3 mutation (62 available)
Tg(BCL2)25Wehi mutation (1 available)
Tg(Lck-cre)1Jtak mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:236298 )
• CD4+ single positive thymocytes

endocrine/exocrine glands
decreased thymocyte number ( J:236298 )
• CD4+ single positive thymocytes

hematopoietic system
decreased thymocyte number ( J:236298 )
• CD4+ single positive thymocytes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory