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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mir196a-2tm1.1Wtsi
targeted mutation 1.1, Wellcome Trust Sanger Institute
MGI:5805881
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mir196a-2tm1.1Wtsi/Mir196a-2tm1.1Wtsi involves: C57BL/6J * C57BL/6N MGI:5805942
cx2
 		Mir196a-2tm1.1Wtsi/Mir196a-2tm1.1Wtsi
Mir196btm1.1Wtsi/Mir196btm1.1Wtsi 		involves: C57BL/6J * C57BL/6N MGI:5805944
cx3
 		Mir196a-1tm1.1Wtsi/Mir196a-1tm1.1Wtsi
Mir196a-2tm1.1Wtsi/Mir196a-2tm1.1Wtsi
Mir196btm1.1Wtsi/Mir196btm1.1Wtsi 		involves: C57BL/6J * C57BL/6N MGI:5805945


Genotype
MGI:5805942
hm1
Allelic
Composition		 Mir196a-2tm1.1Wtsi/Mir196a-2tm1.1Wtsi
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir196a-2tm1.1Wtsi mutation (0 available); any Mir196a-2 mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal sacrum morphology ( J:226712 )
• posterior displacement of the sacrum
lumbar vertebral transformation ( J:226712 )
• the first lumbar vertebra has a rudimentary rib nubbin indicating an anterior homeotic transformation
• one-quarter of mice exhibit anterior homeotic transformation of all lumbar vertebrae
sacral vertebral transformation ( J:226712 )
• one-quarter of mice exhibit anterior homeotic transformation of all sacral elements with posterior displacement of the sacrum




Genotype
MGI:5805944
cx2
Allelic
Composition		 Mir196a-2tm1.1Wtsi/Mir196a-2tm1.1Wtsi
Mir196btm1.1Wtsi/Mir196btm1.1Wtsi
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir196a-2tm1.1Wtsi mutation (0 available); any Mir196a-2 mutation (2 available)
Mir196btm1.1Wtsi mutation (0 available); any Mir196b mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
increased rib number ( J:226712 )
• 2 pairs of supernumerary ribs
vertebral transformation ( J:226712 )
• fully penetrant anterior homeotic transformation of all subsequent elements following supernumerary ribs




Genotype
MGI:5805945
cx3
Allelic
Composition		 Mir196a-1tm1.1Wtsi/Mir196a-1tm1.1Wtsi
Mir196a-2tm1.1Wtsi/Mir196a-2tm1.1Wtsi
Mir196btm1.1Wtsi/Mir196btm1.1Wtsi
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir196a-1tm1.1Wtsi mutation (0 available); any Mir196a-1 mutation (5 available)
Mir196a-2tm1.1Wtsi mutation (0 available); any Mir196a-2 mutation (2 available)
Mir196btm1.1Wtsi mutation (0 available); any Mir196b mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
increased rib number ( J:226712 )
• 2 pairs of supernumerary ribs as in Mir196a-2 and Mir196b double homozygote nulls
vertebral transformation ( J:226712 )
• fully penetrant anterior homeotic transformation of all subsequent elements following supernumerary ribs as in Mir196a-2 and Mir196b double homozygote nulls




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory