All Phenotypes Tcf3<tm1(PBX1)Mlc> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tcf3^tm1(PBX1)Mlc/Tcf3⁺ Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:5825356
cn2	Pax5^tm3Mbu/Pax5⁺ Tcf3^tm1(PBX1)Mlc/Tcf3⁺ Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:5825360
cn3	Tcf3^tm1(PBX1)Mlc/Tcf3⁺ Cd79a^tm1(cre)Reth/Cd79a⁺	involves: BALB/c * C57BL/6	MGI:5825357
cn4	Tcf3^tm1(PBX1)Mlc/Tcf3⁺ Tg(Mx1-cre)1Cgn/0	involves: C57BL/6 * C57BL/6J * CBA/J	MGI:5825359

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased B cell acute lymphoblastic leukemia incidence ( J:226241 )

• mice develop acute leukemia with an incidence of 7% at 12 months of age

• leukemia cells are present in the bone marrow, spleen, lymph nodes and infiltrate multiple organs, including the CNS

• 94% of leukemias have a B cell precursor phenotype

hematopoietic system

enlarged spleen ( J:226241 )

• in leukemic mice

abnormal pro-B cell morphology ( J:226241 )

• progenitor B cells proliferate extensively in methylcellulose culture supplemented with IL-7, SCF, and FLT3 and are severely compromised in the their ability to differentiate into CD43- cells compared with progenitor B cells from controls indicating enhanced proliferation of progenitor B cells

abnormal pro-B cell differentiation ( J:226241 )

• mice show perturbed early B cell progenitor cell differentiation

arrested B cell differentiation ( J:226241 )

• leukemic blasts are arrested at the pro/pre-B stage of B cell precursor differentiation

anemia ( J:226241 )

• in leukemic mice

thrombocytopenia ( J:226241 )

• in leukemic mice

decreased B cell number ( J:226241 )

• a lower percentage of B cells are seen in the peripheral blood over a 30 week period in healthy preleukemic mice

decreased immature B cell number ( J:226241 )

• decrease in immature and recirculating B cells in the bone marrow in healthy preleukemic mice

increased leukocyte cell number ( J:226241 )

• leukemic mice present with leukocytosis

abnormal B cell physiology ( J:226241 )

• enhanced proliferation of progenitor B cells

• preleukemic mice irradiated sublethally to deplete the endogenous B cell populations show regeneration of B cell progenitors with a dramatic expansion of B220^lo progenitor cell population indicating enhanced B cell progenitor self-renewal

immune system

enlarged spleen ( J:226241 )

• in leukemic mice

abnormal pro-B cell morphology ( J:226241 )

abnormal pro-B cell differentiation ( J:226241 )

• mice show perturbed early B cell progenitor cell differentiation

arrested B cell differentiation ( J:226241 )

• leukemic blasts are arrested at the pro/pre-B stage of B cell precursor differentiation

decreased B cell number ( J:226241 )

• a lower percentage of B cells are seen in the peripheral blood over a 30 week period in healthy preleukemic mice

decreased immature B cell number ( J:226241 )

• decrease in immature and recirculating B cells in the bone marrow in healthy preleukemic mice

increased leukocyte cell number ( J:226241 )

• leukemic mice present with leukocytosis

abnormal B cell physiology ( J:226241 )

• enhanced proliferation of progenitor B cells

enlarged lymph nodes ( J:226241 )

• in leukemic mice

liver/biliary system

enlarged liver ( J:226241 )

• in leukemic mice

growth/size/body

enlarged liver ( J:226241 )

• in leukemic mice

enlarged spleen ( J:226241 )

• in leukemic mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute lymphoblastic leukemia		DOID:9952	OMIM:247640 OMIM:613065	J:226241

Allelic Composition	Pax5^tm3Mbu/Pax5⁺ Tcf3^tm1(PBX1)Mlc/Tcf3⁺ Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Pax5^tm3Mbu mutation (1 available); any Pax5 mutation (37 available)
Tcf3^tm1(PBX1)Mlc mutation (0 available); any Tcf3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased B cell acute lymphoblastic leukemia incidence ( J:226241 )

• mice exhibit increased penetrance and accelerated acute leukemia development compared to single Tcf3^tm1(PBX1)Mlc conditional mutants

hematopoietic system

decreased immature B cell number ( J:226241 )

• preleukemic mice show a greater decrease of immature B cells of the Lin-CD19+CD43- fractions compared to Tcf3^tm1(PBX1)Mlc conditional mutants, indicating a more severe block of B cell differentiation at this stage of maturation

abnormal pro-B cell morphology ( J:226241 )

• preleukemic mice show expansion of GFP+ progenitor cells of the Lin-CD19+CD43+ fractions at younger ages compared to single Tcf3^tm1(PBX1)Mlc conditional mutants, indicating accelerated preleukemic progenitor B cell expansion

arrested B cell differentiation ( J:226241 )

immune system

decreased immature B cell number ( J:226241 )

abnormal pro-B cell morphology ( J:226241 )

arrested B cell differentiation ( J:226241 )

Allelic Composition	Tcf3^tm1(PBX1)Mlc/Tcf3⁺ Cd79a^tm1(cre)Reth/Cd79a⁺
Genetic Background	involves: BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Tcf3^tm1(PBX1)Mlc mutation (0 available); any Tcf3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased B cell acute lymphoblastic leukemia incidence ( J:226241 )

• mice develop acute leukemia with an incidence of 53% at 12 months of age

• leukemia cells are present in the bone marrow, spleen, lymph nodes and infiltrate multiple organs, including the CNS

• 94% of leukemias have a B cell precursor phenotype

hematopoietic system

enlarged spleen ( J:226241 )

• in leukemic mice

arrested B cell differentiation ( J:226241 )

• leukemic blasts are arrested at the pro/pre-B stage of B cell precursor differentiation

anemia ( J:226241 )

• in leukemic mice

thrombocytopenia ( J:226241 )

• in leukemic mice

decreased B cell number ( J:226241 )

• a lower percentage of B cells are seen in the peripheral blood over a 30 week period in healthy preleukemic mice

decreased immature B cell number ( J:226241 )

• decrease in immature and recirculating B cells in the bone marrow in healthy preleukemic mice

increased leukocyte cell number ( J:226241 )

• leukemic mice present with leukocytosis

immune system

enlarged spleen ( J:226241 )

• in leukemic mice

arrested B cell differentiation ( J:226241 )

• leukemic blasts are arrested at the pro/pre-B stage of B cell precursor differentiation

decreased B cell number ( J:226241 )

• a lower percentage of B cells are seen in the peripheral blood over a 30 week period in healthy preleukemic mice

decreased immature B cell number ( J:226241 )

• decrease in immature and recirculating B cells in the bone marrow in healthy preleukemic mice

increased leukocyte cell number ( J:226241 )

• leukemic mice present with leukocytosis

enlarged lymph nodes ( J:226241 )

• in leukemic mice

liver/biliary system

enlarged liver ( J:226241 )

• in leukemic mice

growth/size/body

enlarged liver ( J:226241 )

• in leukemic mice

enlarged spleen ( J:226241 )

• in leukemic mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute lymphoblastic leukemia		DOID:9952	OMIM:247640 OMIM:613065	J:226241

Allelic Composition	Tcf3^tm1(PBX1)Mlc/Tcf3⁺ Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: C57BL/6 * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3^tm1(PBX1)Mlc mutation (0 available); any Tcf3 mutation (43 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased B cell acute lymphoblastic leukemia incidence ( J:226241 )

• mice develop acute leukemia with an incidence of 59% at 12 months of age

• leukemia cells are present in the bone marrow, spleen, lymph nodes and infiltrate multiple organs, including the CNS

• 94% of leukemias have a B cell precursor phenotype

hematopoietic system

enlarged spleen ( J:226241 )

• in leukemic mice

arrested B cell differentiation ( J:226241 )

• leukemic blasts are arrested at the pro/pre-B stage of B cell precursor differentiation

anemia ( J:226241 )

• in leukemic mice

thrombocytopenia ( J:226241 )

• in leukemic mice

decreased B cell number ( J:226241 )

• a lower percentage of B cells are seen in the peripheral blood over a 30 week period in healthy preleukemic mice

decreased immature B cell number ( J:226241 )

• decrease in immature and recirculating B cells in the bone marrow in healthy preleukemic mice

increased leukocyte cell number ( J:226241 )

• leukemic mice present with leukocytosis

immune system

enlarged spleen ( J:226241 )

• in leukemic mice

arrested B cell differentiation ( J:226241 )

• leukemic blasts are arrested at the pro/pre-B stage of B cell precursor differentiation

decreased B cell number ( J:226241 )

• a lower percentage of B cells are seen in the peripheral blood over a 30 week period in healthy preleukemic mice

decreased immature B cell number ( J:226241 )

• decrease in immature and recirculating B cells in the bone marrow in healthy preleukemic mice

increased leukocyte cell number ( J:226241 )

• leukemic mice present with leukocytosis

enlarged lymph nodes ( J:226241 )

• in leukemic mice

liver/biliary system

enlarged liver ( J:226241 )

• in leukemic mice

growth/size/body

enlarged liver ( J:226241 )

• in leukemic mice

enlarged spleen ( J:226241 )

• in leukemic mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute lymphoblastic leukemia		DOID:9952	OMIM:247640 OMIM:613065	J:226241

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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