Phenotypes associated with this allele

• Allele Symbol: Lmna^tm12Lgf
• Allele Name: targeted mutation 12, Loren G Fong
• Allele ID: MGI:5806143
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lmna^tm12Lgf/Lmna^tm12Lgf	involves: 129P2/OlaHsd * C57BL/6	MGI:5806144

Genotype
MGI:5806144

hm1

• Allelic Composition: Lmna^tm12Lgf/Lmna^tm12Lgf
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal aorta tunica adventitia morphology ( J:234711 )

• adventitial fibrosis by 4 months of age

abnormal aorta smooth muscle morphology ( J:234711 )

• by 4 months of age, mice show a near-complete loss of smooth muscle cells in the media of the ascending aorta

• mice treated with an exon 11-33 antisense oligonucleotide for 3 months beginning at 1 month of age show improved aortic pathology with less adventitial fibrosis and more smooth muscle cells

muscle

abnormal aorta smooth muscle morphology ( J:234711 )

• by 4 months of age, mice show a near-complete loss of smooth muscle cells in the media of the ascending aorta

• mice treated with an exon 11-33 antisense oligonucleotide for 3 months beginning at 1 month of age show improved aortic pathology with less adventitial fibrosis and more smooth muscle cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
progeria		DOID:3911	OMIM:176670	J:234711