All Phenotypes Ica1l<em1Jxia> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ica1l^em1Jxia
endonuclease-mediated mutation 1, Jun Xia
MGI:5806150

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ica1l^em1Jxia/Ica1l^em1Jxia	involves: C57BL/6 * CBA	MGI:5806227
cx2	Ica1^tm1Mdos/Ica1^tm1Mdos Ica1l^em1Jxia/Ica1l^em1Jxia	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:5806228

Allelic Composition	Ica1l^em1Jxia/Ica1l^em1Jxia
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ica1l^em1Jxia mutation (0 available); any Ica1l mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal sperm mitochondrial sheath morphology ( J:233657 )

oligozoospermia ( J:233657 )

• in the cauda epididymis

• reduced mobile and linear mobile sperm form the cauda epididymis

abnormal sperm nucleus morphology ( J:233657 )

• smaller and irregular compared with wild-type sperm

abnormal spermiogenesis ( J:233657 )

• with round nuclei sperm

globozoospermia ( J:233657 )

decreased litter size ( J:233657 )

• reduced litter size produced from male mice

reduced male fertility ( J:233657 )

• with reduced litter size

cellular

abnormal sperm mitochondrial sheath morphology ( J:233657 )

oligozoospermia ( J:233657 )

• in the cauda epididymis

• reduced mobile and linear mobile sperm form the cauda epididymis

globozoospermia ( J:233657 )

abnormal sperm nucleus morphology ( J:233657 )

• smaller and irregular compared with wild-type sperm

Allelic Composition	Ica1^tm1Mdos/Ica1^tm1Mdos Ica1l^em1Jxia/Ica1l^em1Jxia
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ica1l^em1Jxia mutation (0 available); any Ica1l mutation (25 available)
Ica1^tm1Mdos mutation (1 available); any Ica1 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal sperm mitochondrial sheath morphology ( J:233657 )

oligozoospermia ( J:233657 )

• severe reduction in total and mobile sperm number with complete loss of linear mobile sperm

• in cauda epididymis

abnormal acrosome morphology ( J:233657 )

• fragmented or completely lost

globozoospermia ( J:233657 )

absent acrosome ( J:233657 )

• in some sperm

abnormal sperm nucleus morphology ( J:233657 )

• smaller and irregular compared with wild-type sperm

abnormal spermiogenesis ( J:233657 )

• with round nuclei sperm

male infertility ( J:233657 )

cellular

abnormal sperm mitochondrial sheath morphology ( J:233657 )

oligozoospermia ( J:233657 )

• severe reduction in total and mobile sperm number with complete loss of linear mobile sperm

• in cauda epididymis

abnormal acrosome morphology ( J:233657 )

• fragmented or completely lost

globozoospermia ( J:233657 )

absent acrosome ( J:233657 )

• in some sperm

abnormal sperm nucleus morphology ( J:233657 )

• smaller and irregular compared with wild-type sperm

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