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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ica1lem1Jxia
endonuclease-mediated mutation 1, Jun Xia
MGI:5806150
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ica1lem1Jxia/Ica1lem1Jxia involves: C57BL/6 * CBA MGI:5806227
cx2
Ica1tm1Mdos/Ica1tm1Mdos
Ica1lem1Jxia/Ica1lem1Jxia
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:5806228


Genotype
MGI:5806227
hm1
Allelic
Composition
Ica1lem1Jxia/Ica1lem1Jxia
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ica1lem1Jxia mutation (0 available); any Ica1l mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• in the cauda epididymis
• reduced mobile and linear mobile sperm form the cauda epididymis
• smaller and irregular compared with wild-type sperm
• with round nuclei sperm
• reduced litter size produced from male mice
• with reduced litter size

cellular
• in the cauda epididymis
• reduced mobile and linear mobile sperm form the cauda epididymis
• smaller and irregular compared with wild-type sperm




Genotype
MGI:5806228
cx2
Allelic
Composition
Ica1tm1Mdos/Ica1tm1Mdos
Ica1lem1Jxia/Ica1lem1Jxia
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ica1lem1Jxia mutation (0 available); any Ica1l mutation (25 available)
Ica1tm1Mdos mutation (1 available); any Ica1 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• severe reduction in total and mobile sperm number with complete loss of linear mobile sperm
• in cauda epididymis
• fragmented or completely lost
• in some sperm
• smaller and irregular compared with wild-type sperm
• with round nuclei sperm

cellular
• severe reduction in total and mobile sperm number with complete loss of linear mobile sperm
• in cauda epididymis
• fragmented or completely lost
• in some sperm
• smaller and irregular compared with wild-type sperm





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory