All Phenotypes Ppp3cb<M1Btlr> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppp3cb^M1Btlr/Ppp3cb^M1Btlr	C57BL/6J-Ppp3cb^M1Btlr	MGI:5807108
ht2	Ppp3cb^M1Btlr/Ppp3cb⁺	C57BL/6J-Ppp3cb^M1Btlr	MGI:5807109

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased CD8-positive, alpha-beta memory T cell proliferation ( J:236670 )

• increased frequency of central memory CD8+ T cells

abnormal NK cell physiology ( J:236670 )

• some mice show increased expression of CD44 on CD8+ T cells and an increased frequency of NK cells in the peripheral blood

abnormal CD4-positive, alpha-beta T cell physiology ( J:236670 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

abnormal CD8-positive, alpha-beta T cell physiology ( J:236670 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

cellular

increased CD8-positive, alpha-beta memory T cell proliferation ( J:236670 )

• increased frequency of central memory CD8+ T cells

hematopoietic system

increased CD8-positive, alpha-beta memory T cell proliferation ( J:236670 )

• increased frequency of central memory CD8+ T cells

abnormal NK cell physiology ( J:236670 )

• some mice show increased expression of CD44 on CD8+ T cells and an increased frequency of NK cells in the peripheral blood

abnormal CD4-positive, alpha-beta T cell physiology ( J:236670 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

abnormal CD8-positive, alpha-beta T cell physiology ( J:236670 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

Allelic Composition	Ppp3cb^M1Btlr/Ppp3cb⁺
Genetic Background	C57BL/6J-Ppp3cb^M1Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3cb^M1Btlr mutation (0 available); any Ppp3cb mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased CD8-positive, alpha-beta memory T cell proliferation ( J:236670 )

• increased frequency of central memory CD8+ T cells

abnormal NK cell physiology ( J:236670 )

• some mice show increased expression of CD44 on CD8+ T cells and an increased frequency of NK cells in the peripheral blood

abnormal CD4-positive, alpha-beta T cell physiology ( J:236670 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

abnormal CD8-positive, alpha-beta T cell physiology ( J:236670 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

cellular

increased CD8-positive, alpha-beta memory T cell proliferation ( J:236670 )

• increased frequency of central memory CD8+ T cells

hematopoietic system

increased CD8-positive, alpha-beta memory T cell proliferation ( J:236670 )

• increased frequency of central memory CD8+ T cells

abnormal NK cell physiology ( J:236670 )

• some mice show increased expression of CD44 on CD8+ T cells and an increased frequency of NK cells in the peripheral blood

abnormal CD4-positive, alpha-beta T cell physiology ( J:236670 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

abnormal CD8-positive, alpha-beta T cell physiology ( J:236670 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24