All Phenotypes Ppp3cb<m2Btlr> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppp3cb^m2Btlr/Ppp3cb^m2Btlr	C57BL/6J-Ppp3cb^m2Btlr	MGI:5807111
ht2	Ppp3cb^m2Btlr/Ppp3cb⁺	C57BL/6J-Ppp3cb^m2Btlr	MGI:5807112

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased CD8-positive, alpha-beta memory T cell proliferation ( J:236671 )

• an increased frequency of central memory CD8+ T cells, an increased frequency of effector memory CD8+ T cells and a reduced frequency of nave CD8+ T cells, all in the peripheral blood

abnormal NK cell physiology ( J:236671 )

• some mice exhibit increased expression of CD44 on T cells and on CD8+ T cells as well as an increased frequency of NK cells

abnormal CD4-positive, alpha-beta T cell physiology ( J:236671 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

abnormal CD8-positive, alpha-beta T cell physiology ( J:236671 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

decreased response to antigen ( J:236671 )

• T-dependent antibody response to ovalbumin administered with aluminum hydroxide is also diminished

cellular

increased CD8-positive, alpha-beta memory T cell proliferation ( J:236671 )

• an increased frequency of central memory CD8+ T cells, an increased frequency of effector memory CD8+ T cells and a reduced frequency of nave CD8+ T cells, all in the peripheral blood

hematopoietic system

increased CD8-positive, alpha-beta memory T cell proliferation ( J:236671 )

• an increased frequency of central memory CD8+ T cells, an increased frequency of effector memory CD8+ T cells and a reduced frequency of nave CD8+ T cells, all in the peripheral blood

abnormal NK cell physiology ( J:236671 )

• some mice exhibit increased expression of CD44 on T cells and on CD8+ T cells as well as an increased frequency of NK cells

abnormal CD4-positive, alpha-beta T cell physiology ( J:236671 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

abnormal CD8-positive, alpha-beta T cell physiology ( J:236671 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

Allelic Composition	Ppp3cb^m2Btlr/Ppp3cb⁺
Genetic Background	C57BL/6J-Ppp3cb^m2Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3cb^m2Btlr mutation (0 available); any Ppp3cb mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased CD8-positive, alpha-beta memory T cell proliferation ( J:236671 )

• an increased frequency of central memory CD8+ T cells, and an increased frequency of effector memory CD8+ T cells, all in the peripheral blood

abnormal CD4-positive, alpha-beta T cell physiology ( J:236671 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

abnormal CD8-positive, alpha-beta T cell physiology ( J:236671 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

cellular

increased CD8-positive, alpha-beta memory T cell proliferation ( J:236671 )

• an increased frequency of central memory CD8+ T cells, and an increased frequency of effector memory CD8+ T cells, all in the peripheral blood

hematopoietic system

increased CD8-positive, alpha-beta memory T cell proliferation ( J:236671 )

• an increased frequency of central memory CD8+ T cells, and an increased frequency of effector memory CD8+ T cells, all in the peripheral blood

abnormal CD4-positive, alpha-beta T cell physiology ( J:236671 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

abnormal CD8-positive, alpha-beta T cell physiology ( J:236671 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24