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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rac2m3Btlr
mutation 3, Bruce Beutler
MGI:5806333
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rac2m3Btlr/Rac2m3Btlr C57BL/6J-Rac2m3Btlr MGI:5807145
ht2
 		Rac2m3Btlr/Rac2+ C57BL/6J-Rac2m3Btlr MGI:5807146


Genotype
MGI:5807145
hm1
Allelic
Composition		 Rac2m3Btlr/Rac2m3Btlr
Genetic
Background		 C57BL/6J-Rac2m3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rac2m3Btlr mutation (0 available); any Rac2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:236680 )
• B cells and IgM+ B cells
decreased IgM level ( J:236680 )
• diminished T-independent IgM response to 4-hydroxy-3-nitrophenylacetyl-Ficoll
decreased response to antigen ( J:236680 )
• diminished T-independent IgM response to 4-hydroxy-3-nitrophenylacetyl-Ficoll

hematopoietic system
decreased B cell number ( J:236680 )
• B cells and IgM+ B cells
decreased IgM level ( J:236680 )
• diminished T-independent IgM response to 4-hydroxy-3-nitrophenylacetyl-Ficoll




Genotype
MGI:5807146
ht2
Allelic
Composition		 Rac2m3Btlr/Rac2+
Genetic
Background		 C57BL/6J-Rac2m3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rac2m3Btlr mutation (0 available); any Rac2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

immune system




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory